Effects of natalizumab therapy on intrathecal antiviral antibody responses in MS

Conclusions These data indicate that JCV-specific antibodies are produced intrathecally in a minority of patients with MS, and NAT treatment affects the intrathecal humoral immune response against JCV relatively specifically compared with other neurotropic viruses. Further studies are needed to determine whether this effect translates to higher risk of progressive multifocal leukoencephalopathy development.
Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Authors: Tags: Cerebrospinal Fluid, Multiple sclerosis Article Source Type: research