Active treatment in low-risk prostate cancer: a population-based study.
Conclusions: This contemporary population-based study demonstrates that approximately one third of patients with lr-pca undergo at. Patients of younger age, with less comorbidity, a higher tumour stage, higher psa, earlier year of diagnosis, and radiation oncologist consultation were more likely to undergo at. Further investigation is needed to identify strategies that could minimize overtreatment. PMID: 31548822 [PubMed - in process]
Publication date: Available online 11 November 2019Source: Biosensors and BioelectronicsAuthor(s): Parham Ghassemi, Xiang Ren, Brittni M. Foster, Bethany A. Kerr, Masoud AgahAbstractCirculating tumor cells (CTCs) in blood can provide valuable information when detecting, diagnosing, and monitoring cancer. This paper describes a system that consists of a constriction-based microfluidic sensor with embedded electrodes that can detect and enumerate cancer cells in blood. The biosensor measures impedance in terms of magnitude and phase at multiple frequencies as cells transit through the constriction channel. Cancer cells defor...
Conclusion: These findings suggest that a pro-inflammatory diet is a risk factor for prostate cancer and also can have the impact on body composition.
ConclusionsThe intervention was associated with increased patient knowledge. Data from this pilot have guided the development of a larger scale randomized clinical trial to improve decision quality in men with prostate cancer being treated in community settings.
PROSTATE cancer is the most common cancer in men in the UK and it usually develops slowly, so there may be no signs for many years. Advanced prostate cancer means the cancer has spread to other parts of the body, and experiencing pain in different areas of the body may signal the cancer has spread.
Night-shift work has been shown to be associated with breast cancer risk. Might it also play a role in prostate cancer development?American Journal of Epidemiology
(Children's National Hospital) Using CRISPR/Cas9 knockout screens, a multi-institutional research team systematically interrogated the essentiality of more than 10,000 forkhead box protein A1 (FOXA1) and CTCF binding sites in breast and prostate cancer cells, finding that essential FOXA1 binding sites act as enhancers to orchestrate the expression of nearby essential genes.
Authors: Anttinen M PMID: 31701789 [PubMed - as supplied by publisher]
This study was registered with Japan Registry of Clinical Trials (jRCTs052190026). PMID: 31701044 [PubMed]
Conclusion: LDR-EBRT may provide more effective PSA control at 5 years compared with HDR-EBRT. Direct comparison of these treatments through randomised trials are recommended to investigate this hypothesis further. PMID: 31701035 [PubMed]
Adjuvant (ART) and salvage radiotherapy (SRT) are two common concepts to enhance biochemical relapse free survival (BCRFS) in patients with prostate cancer (PC). We analyzed differences in outcome between ART ...