Association between fine mapping thymic stromal lymphopoietin and atopic dermatitis onset and persistence
Atopic dermatitis (AD) is a common chronic relapsing skin disease. Genetic variants have been associated with skin barrier function and immune regulation. Thymic stromal lymphopoietin (TSLP), an immune regulator, has been previously associated with AD.
CONCLUSIONS: Our results suggest that the status of the gut microbiota in early life in the mouse may play a crucial role in AD development through intestinal SCFA production through regulate the numbers of CD4⁺IL17⁺/CD4⁺FOXP3⁺ regulatory T cells and ILC3s. PMID: 31743970 [PubMed]
A subspecialist friend of mine once told me, in jest, “get an organ” as we were debating over which of us should manage a disease that overlapped in both of our specialties. However, to do so is impossible in the field of allergy. As allergist-immunologists, we quickly came to understand that allergic diseases are immunologic, and by definition, in volve the entire body. It is true that many allergic diseases manifest predominantly in 1 organ, such as asthma involving the lung or atopic dermatitis involving the skin, yet all allergic diseases are systemic.
AbstractThe European Academy of Allergy and Clinical Immunology (EAACI) supports three journals: Allergy, Paediatric Allergy and Immunology as well as Clinical and Translational Allergy. The major goals of EAACI include (i) supporting health promotion in which the prevention of allergy and asthma plays a critical role and (ii) disseminating the knowledge of allergy to all stakeholders including the EAACI junior members. Substantial progress was made in 2018 in the identification of basic mechanisms of atopic dermatitis and urticaria and the translation of t hese mechanisms into clinics. Many large epidemiologic studi...
The objective of this study was to test the hypothesis that comorbid type 2 immune diseases confer protection against morbidity and mortality due to acute infection. Design: Retrospective cohort study of patients hospitalized with an acute infection between November 2008 and January 2016 using electronic health record data. Setting: Single tertiary-care academic medical center. Patients: Admissions to the hospital through the emergency department with likely infection at the time of admission who may or may not have had a type 2 immune-mediated disease, defined as asthma, allergic rhinitis, atopic dermatitis, or f...
CONCLUSION: Our results lend further support for an immunosuppressive effect of PFASs on AD and LRTI. Gender seems to be important for some exposure-health associations. No clear pattern in exposure-health associations was observed with regard to exposure period or study design, with the exception of asthma where significant findings have mostly been reported in cross-sectional studies. PMID: 31733527 [PubMed - as supplied by publisher]
This article reviews the role of ILC in allergic skin diseases with a major focus on ILC2. While group 2 ILC are suggested to contribute to the pathogenesis of type 2 dominated inflammation as seen in atopic dermatitis, we have shown that lack of ILC2 in type 1 dominated contact hypersensitivity results in enhanced inflammation, suggesting a regulatory role of ILC2 in this context. We provide a concept of how ILC2 may influence context dependent the mutual counterbalance between type I and type II immune responses in allergic skin diseases.
Atopic dermatitis (AD) may impact health related quality of life (HRQOL) from a combination of signs, symptoms and comorbid anxiety, depression, and other atopic disease1, 2. Quality adjusted life years (QALYs) is a measure of health status and used in cost-effectiveness research. QALYs are estimated using health utility weights, where zero is the worst possible state of health and one is equivalent to perfect health. However, few studies examined the impact of AD on health utility scores.
The immediate priority for clinicians managing patients with atopic dermatitis (AD) is treating the disease, particularly the constant itch and sleep disturbance, with its consequential disruption of both home and work life and association with low mood, poorer concentration, and productivity. However, long-term sequelae are important to consider and include those directly related to the atopic march (asthma, allergic rhinoconjunctivitis, and food allergies), the consequences of having a chronic disease, and potential side effects of therapy, particularly topical corticosteroids.
PMID: 31698096 [PubMed - as supplied by publisher]
Atopic disorders are allergic conditions mediated by allergen-specific IgE. These diseases include asthma, rhinoconjunctivitis and atopic dermatitis (AD) among others. Susceptibility to their development depends on the interaction between genetic and environmental factors . The rapid increase in the prevalence of these disorders during the last 50 years points to environmental changes as the main responsible factors for the observed increment . Epidemiological data allowed to establish a negative correlation between the increase in allergies and the prevalence of certain infections, leading to the elaboration of the ...