RAB18 modulates autophagy in human stellate  cells

Macroautophagy (or autophagy) is a conserved degradative pathway that breaks down sequestered cytoplasmic proteins and organelles in specialized double-membrane compartments called autophagosomes that fuse with lysosomes. Several proteins orchestrate this process, specifically Rab GTPases that are master regulators of molecular trafficking. RAB18 GTPase, a known mediator of stellate cell activation, is known to modulate autophagic flux in fibroblasts. However, its role in autophagy is unexplored in hepatic stellate cells.

Source: Journal of Clinical Lipidology - July 24, 2019 Category: Lipidology Authors: Soumik BasuRay Tags: Original Research Source Type: research