Lipid-based Vehicles for siRNA Delivery in Biomedical Field.

Lipid-based Vehicles for siRNA Delivery in Biomedical Field.
Curr Pharm Biotechnol. 2019 Sep 24;:
Authors: Li T, Huang L, Yang M
Abstract
Genetic drugs have aroused much attention in the past twenty years. RNA interference (RNAi) offers novel insights into discovering potential gene functions and therapies targeting genetic diseases. Small interference RNA (siRNA), typically 21-23 nucleotides in length, can specifically degrade complementary mRNA. However, targeted delivery and controlled release of siRNA remain a great challenge. Considering the vast number of drug carriers, when compared with viral vectors, non-viral ones show reduced cytotoxicity and low production cost. Especially, lipid-based vehicles are more promising due to their high biocompatibility and bioavailability. In this review, different types of lipid-based carriers and their functioning mechanisms are discussed. We also aim to review the targeting strategies and applications of siRNA delivery in biomedical fields.
PMID: 31549951 [PubMed - as supplied by publisher]

Source: Current Pharmaceutical Biotechnology - September 23, 2019 Category: Biotechnology Authors: Li T, Huang L, Yang M Tags: Curr Pharm Biotechnol Source Type: research