Laparoscopic Resection After Neoadjuvant Chemotherapy for Distal Gastric Tumors

In this study, an open-label, single cente r, phase 2 randomized clinical trial with a noninferiority design, the authors assessed outcomes at 3 years. All patients received neoadjuvant therapy of oxaliplatin and capecitabine before their operation. Li and colleagues reported significantly lower postoperative complication rates, less postope rative pain, and better adherence to and completion of adjuvant therapy among trial participants.
Source: JAMA Surgery - Category: Sports Medicine Source Type: research

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Karel Pekarek's terminal cancer went undiagnosed after two visits to two emergency rooms in B.C.'s Lower Mainland in June. His family knows an earlier diagnosis may not have saved his life, but they say it could have eased his pain as he died.
Source: CBC | Health - Category: Consumer Health News Tags: News/Canada/British Columbia Source Type: news
Publication date: Available online 9 December 2019Source: European Journal of Integrative MedicineAuthor(s): Xiao-Qing Wang, Pei-Bei Duan, Man Zheng, Qian Xu, Li-Hua Yang, A-Qin WangAbstractIntroductionAuricular acupuncture has been used for pain management. A more recent technique which buries an intradermal needle into the skin may provides long lasting stimulation and enhance analgesia. The purpose of this study was to evaluate the efficacy and feasibility of perioperative auricular acupuncture technique via intradermal needling buried on postoperative movement-evoked pain reduction of patients with advanced gastric can...
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
Cancers, Vol. 11, Pages 1987: Phase 1 Dose Escalation Study of the Allosteric AKT Inhibitor BAY 1125976 in Advanced Solid Cancer—Lack of Association between Activating AKT Mutation and AKT Inhibition-Derived Efficacy Cancers doi: 10.3390/cancers11121987 Authors: Andreas Schneeweiss Dagmar Hess Markus Joerger Andrea Varga Stacy Moulder Apostolia M. Tsimberidou Cynthia Ma Sara A. Hurvitz Christine Rentzsch Marion Rudolph Silke Thiele Oliver Boix Gary Wilkinson Eleni Lagkadinou Matthias Ocker This open-label, phase I first-in-human study (NCT01915576) of BAY 1125976, a highly specific...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
The objective response rate (ORR) was 30% (10/33), including three complete responses (CR) (9.1%) and seven partial responses (PR) (21.2%) and a disease control rate (DCR = CR + PR + SD) of 66.7% (22 of 33). The most common adverse reactions, blistering, subcutaneous fat induration, local heat-related pain, vomiting and sinus tachycardia, were observed in association with HT. IL-2, IL-4, TNF-α, and IFN-γ levels in peripheral blood were significantly increased among the clinical responders (p 
Source: International Journal of Hyperthermia - Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research
ConclusionWe need to perform more cases for future comparative studies with percutaneous endoscopic intragastric surgery [PEIGS] in terms of parameters as pain, inflammation, complications, stenosis, oncological results and cosmesis.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Authors: Pu J, Wang N, Huang ZK, He XY, Yuan HB Abstract OBJECTIVE: To explore the correlation between gene polymorphism and opioid efficacy in patients with gastric or intestinal cancer. PATIENTS AND METHODS: Fifty-nine patients who underwent laparoscopic surgery for gastric or intestinal cancer under general anesthesia were included and randomly divided into oxycodone (n=30) and sufentanil groups (n=29) by reproducible random number generation method. Single nucleotide polymorphisms (SNPs) of four alleles: μ-opioid receptor gene OPRM1 A118G, cytochrome P450 (CPY450) enzyme system: CPY3A4*1G, CYP3A5*3, and ...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
It’s in the early morning of April 15th, 2030 that when looking at your smart mirror, the latter beeps a warning notification: that new mole on your chin should be checked by your dermatologist. That was to be expected. After all your genetic test revealed that you possess a mutation in the CDKN2A gene. But you also get the recommendation to have your esophagus and stomach checked as your connected smart scale registered a noticeable drop in weight and this mutation also carries an increased risk of gastrointestinal (GI) tract cancer. With such increased awareness and early stage diagnosis methods, will the cance...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine Personalized Medicine cancer digital health cancer treatment digital technology oncology cancer research cancer care digital health technologies Source Type: blogs
BOSTON (CBS) — Many patients diagnosed with cancer undergo chemotherapy, radiation, surgery or all three. According to a new survey, some wish they had been given more information about side effects. Researchers surveyed more than 400 adults. The survey found that while nine in ten patients felt they had made the right decision about treatment, one in three developed side effects they wish they had known more about. With radiation, patients wished they had known about skin irritation, stomach upset symptoms and fatigue. For patients receiving chemotherapy, they said they wanted more information on nerve damage, stoma...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Healthwatch Syndicated Local Cancer Treatment Chemotherapy Dr. Mallika Marshall Radiation Treatment Side Effects Source Type: news
Conclusions: Laparoscopic distal gastrectomy with D2 lymphadenectomy for locally advanced gastric cancer shows benefits in terms of lower complication rate, faster recovery, and less pain compared with open surgery.
Source: Annals of Surgery - Category: Surgery Tags: RANDOMIZED CONTROLLED TRIALS Source Type: research
This study was conducted to assess the outcomes of all resectable gastric cancers that presented to our tertiary cancer center in Northeast India. All patients undergoing upfront surgery for gastric cancer with curative intention between 2012 and 2017 were included in the study. A total of 116 patients who underwent upfront radical gastrectomy were included in the study. Males (58.6%) were more common than females (41.4%). Mean age at presentation was 56.12 years (range 26 –89). The most common mode of presentation was pain abdomen (53.8%). The most common location of tumor was the distal part (81%) followed by the p...
Source: Indian Journal of Surgical Oncology - Category: Cancer & Oncology Source Type: research
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