Acanthamoeba keratitis in Australia: demographics, associated factors, presentation and outcomes: a 15-year case review

Eye, Published online: 25 September 2019; doi:10.1038/s41433-019-0589-6Acanthamoeba keratitis in Australia: demographics, associated factors, presentation and outcomes: a 15-year case review
Source: Eye - Category: Opthalmology Authors: Source Type: research

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Authors: Burgos-Blasco B, Arriola-Villalobos P, Ariño-Gutiérrez M, Gegúndez-Fernández JA, Díaz-Valle D PMID: 31973972 [PubMed - as supplied by publisher]
Source: Journal Francais d Ophtalmologie - Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research
In this study, amoebicidal effect of tert-butyl hydroperoxide (tBHP) was investigated and its efficacy was compared to those of hydrogen peroxide (H2O2). H2O2 and tBHP showed dose dependent amoebicidal effect, however high concentration of these compounds demonstrated cytotoxicity in human corneal epithelial (HCE) cells. To reduce their cytotoxicity, the concentrations of both compounds were diluted to 50 μM and subsequently combined with 10 μM vorinostat to enhance amoebicidal effect. Addition of vorinostat induced high amoebicidal effect against Acanthamoeba trophozoites, even at low concentrations of H2O2 or t...
Source: Experimental Parasitology - Category: Parasitology Authors: Tags: Exp Parasitol Source Type: research
Conclusions: Combinatorial treatments showed high amoebicidal effects on Acanthamoeba and low CPEs on HCE cells, which suggests their potential application for Acanthamoeba keratitis treatment.
Source: Cornea - Category: Opthalmology Tags: Basic Investigation Source Type: research
Conclusion. Rns genotyping is very effective in identifying the Acanthamoeba species and genotype in keratitis. Genotyping of Acanthamoeba spp. will help to advance our understanding of genotype-specific pathogenesis and geographical distribution. PMID: 31846414 [PubMed - as supplied by publisher]
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research
Conclusions: Oral miltefosine may have cysticidal properties and should be considered as adjunctive therapy for the treatment of AK, particularly in cases with a significant burden of cysts or in cases recalcitrant to other treatments. PMID: 31829774 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
In this study, 10 rhizosphere samples were collected from maize and alfalfa plants in experimental station at Institute of Genetics, Microbiology and Biotechnology, Szent István University. We detected Acanthamoeba based on the quantitative real-time PCR assay and sequence analysis of the 18S rRNA gene. All studied molecular biological methods are suitable for the detection of Acanthamoeba infection in humans. The quantitative real-time PCR-based methods are more sensitive, simple, and easy to perform; moreover, these are opening avenue to detect the effect of number of parasites on human disease. Acanthamoeba speci...
Source: Acta Microbiologica et Immunologica Hungarica - Category: Microbiology Authors: Tags: Acta Microbiol Immunol Hung Source Type: research
Purpose Microbial contamination of contact lens storage cases is associated with corneal disease ranging from sterile keratitis to sight threatening infections including bacterial and Acanthamoeba keratitis. Given the increasing association between water contact and contact lens-related disease, this study aimed to explore the effect of water contact and storage case contamination in habitual daily wear contact lens users.
Source: Contact Lens and Anterior Eye - Category: Opthalmology Authors: Source Type: research
[Acanthamoeba endophthalmitis-a case report]. Ophthalmologe. 2019 Nov 25;: Authors: Pascha J, Frings A, Walochnik J, Wissiak E, Dirisamer M, Daas L, Ardjomand N Abstract Diagnosis of acanthamoeba keratitis is often a clinical challenge. In most cases it is primarily confused with herpes keratitis. A coinfection with bacteria or fungi can also lead to a delayed diagnosis and initiation of treatment. A few cases reported the detection of acanthamoeba in the anterior chamber. In the case of endophthalmitis without the detection of bacteria or fungi acanthamoeba should therefore always be c...
Source: Der Ophthalmologe - Category: Opthalmology Authors: Tags: Ophthalmologe Source Type: research
Authors: Tananuvat N, Techajongjintana N, Somboon P, Wannasan A Abstract Acanthamoeba keratitis (AK) is a rare sight-threatening corneal infection, often reporting from contact lens wearers. An asymptomatic human immunodeficiency virus (HIV)-infected Thai male without history of contact lens use complained foreign body sensation at his left eye during motorbike riding. He had neither specific keratitis symptoms nor common drugs responding, which contributed to delayed diagnosis. By corneal re-scraping, Acanthamoeba-like cysts were detected by calcofluor white staining and agar culture. The etiological agent obtaine...
Source: Korean Journal of Parasitology - Category: Parasitology Tags: Korean J Parasitol Source Type: research
Publication date: Available online 18 October 2019Source: Journal of the Formosan Medical AssociationAuthor(s): Teck Boon Tew, Hsiao-Sang Chu, Yu-Chih Hou, Wei-Li Chen, I-Jong Wang, Fung-Rong HuPurposeTo study the surgical outcome of therapeutic penetrating keratoplasty (TPK) for medically uncontrolled microbial keratitis at a tertiary hospital in Taiwan over a 14-year period.MethodsThis is a retrospective case series study. Patients who underwent TPK at National Taiwan University Hospital in 2001–2014 were included. Patients were divided into 3 diagnostic groups: bacterial keratitis, fungal keratitis, and acanthamoe...
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
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