Epithelioid rhabdomyosarcoma of the oral cavity, novel location of a rare entity: a case report

ConclusionsEpithelioid rhabdomyosarcoma is a rare variant of rhabdomyosarcoma. To the best of our knowledge, none has been reported in the oral cavity region; thus, this is the first case of this aggressive variant described in this location. This entity may develop without any apparent symptoms or signs of a malignant entity, thus mimicking the appearance of a benign neoplasm or inflammatory process. A comprehensive multidisciplinary approach is advised to diagnose and treat this entity accordingly.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research

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Publication date: Available online 28 May 2020Source: Pathology - Research and PracticeAuthor(s): Florinda Feroce, Monica Cantile, Gabriella Aquino, Francesca Collina, Giosuè Scognamiglio, Luigi Castaldo, Sisto Perdonà, Gerardo Botti, Annarosaria De Chiara
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Abstract Fibroblast growth factor receptor 4 (FGFR4) aberrant expression and activity have been linked to the pathogenesis of a variety of cancers including rhabdomyosarcomas (RMS). We found that treatment of alveolar rhabdomyosarcoma (aRMS) cells with Guadecitabine (SGI-110), a next-generation DNA methyltransferase inhibitor (DNMTi), resulted in a significant reduction of FGFR4 protein levels, 5 days post treatment. Chromatin immunoprecipitation-sequencing (ChIP-seq) in aRMS cells revealed attenuation of the H3K4 mono-methylation across the FGFR4 super enhancer without changes in tri-methylation of either H3K4 ...
Source: Neoplasia - Category: Cancer & Oncology Authors: Tags: Neoplasia Source Type: research
Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma. There are two subtypes, fusion gene-positive RMS (FP-RMS) and fusion gene-negative RMS (FN-RMS), depending on the presence of a fusion g...
Source: Cancer Cell International - Category: Cancer & Oncology Authors: Tags: Primary research Source Type: research
Publication date: Available online 21 May 2020Source: Journal of Pediatric Surgery Case ReportsAuthor(s): Ho Huu Thien, Nguyen Thi Kim Hoa, Phan Canh Duy, Rodgiuez-Galindo Carlos, Nguyen Huu Son
Source: Journal of Pediatric Surgery Case Reports - Category: Surgery Source Type: research
CONCLUSION: PET-CT may not have high sensitivity and specificity to identify bone marrow involvement for each type of cancer. The approach of using bone marrow biopsy and PET-CT as complementary modalities seems reliable. PMID: 32419409 [PubMed - in process]
Source: The Turkish Journal of Pediatrics - Category: Pediatrics Authors: Tags: Turk J Pediatr Source Type: research
ConclusionsReasons for age-related survival differences, and differences in time-trend by age group, are not clear. The significant narrowing of survival differences by age in more recent years for lymphoid leukaemias reflects a more marked recent increase in survival among AYA. More work is required to explain and improve other age-related survival differences.
Source: Irish Journal of Medical Science - Category: General Medicine Source Type: research
Condition:   Rhabdomyosarcoma Interventions:   Drug: Vincristine;   Drug: Cyclophosphamide;   Drug: Vinorelbine;   Drug: Actinomycin D;   Drug: Cyclophosphamide Pill Sponsors:   H. Lee Moffitt Cancer Center and Research Institute;   National Pediatric Cancer Foundation Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionThe E.N.T. malignancies in children are rare and constitutes 20% of all paediatric malignancies. Carcinoma was found more common (68%) than the sarcoma (32%). The nasopharynx and laryngopharynx were found to be the most common sites. They usually present with features that are common in benign illnesses thereby masking the serious nature of the disease. However, the awareness about these tumours and complete examination and early imaging studies and biopsy in suspected children can secure early diagnosis. Radiation therapy is commonly used either alone or with chemotherapy. Radiotherapy can also be given either b...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - Category: ENT & OMF Source Type: research
Conclusions: The proposed nomogram is a reliable and robust tool for accurate prognostic prediction in patients with extremity soft tissue LMS. Introduction Soft tissue leiomyosarcoma (LMS) is an aggressive sarcoma, which originates from smooth muscle cells (1). Soft tissue LMS accounts for about 5–10% of all soft tissue sarcomas (2). It occurs in different sites, including the retroperitoneum, intraabdominal sites, and extremities (3). Extremity LMS comprised about 10–15% of extremity sarcomas, with a preference for the lower limb (4–6). Extremity LMS tends to have a better prognosis than uterine...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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