Circadian clock-controlled drug metabolism and transport.
Circadian clock-controlled drug metabolism and transport.
Xenobiotica. 2019 Sep 23;:1-42
Authors: Zhao M, Xing H, Chen M, Dong D, Wu B
Abstract
1. Metabolism and transport of many drugs oscillate with times of the day (solar time), resulting in circadian time-dependent drug exposure and pharmacokinetics. 2. Time-dependent pharmacokinetics (also known as chronopharmacokinetics) is associated with time-varying drug effects and toxicity. 3. This review summarizes drug-metabolizing enzymes and transporters with rhythmic expressions in the liver, intestine and/or kidney. Correlations of these diurnal proteins with circadian variations in drug exposure and effects/toxicity are covered. We also discuss the molecular mechanisms for circadian control of enzymes and transporters. 4. Mechanism-based chronopharmacokinetics would facilitate a better understanding of chronopharmacology and the design of time-specific drug delivery systems, ultimately leading to improved drug efficacy and minimized toxicity.
PMID: 31544568 [PubMed - as supplied by publisher]
Source: Xenobiotica - Category: Research Authors: Zhao M, Xing H, Chen M, Dong D, Wu B Tags: Xenobiotica Source Type: research