High glucose induces upregulation of scavenger receptors and promotes maturation of dendritic cells

Conclusion: High glucose can increase the expression of the scavenger receptors SR-A, CD36 and LOX-1, which can increase the oxLDL-uptake capacity of DCs. High glucose induces a proinflammatory cytokine profile in human DCs, leading to DC maturation. These results support the hypothesis that atherosclerosis is aggravated by hyperglycaemia-induced DC activation and oxLDL uptake.
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Source Type: research