High glucose induces upregulation of scavenger receptors and promotes maturation of dendritic cells
Conclusion:
High glucose can increase the expression of the scavenger receptors SR-A, CD36 and LOX-1, which can increase the oxLDL-uptake capacity of DCs. High glucose induces a proinflammatory cytokine profile in human DCs, leading to DC maturation. These results support the hypothesis that atherosclerosis is aggravated by hyperglycaemia-induced DC activation and oxLDL uptake.
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Hao LuKang YaoDong HuangAijun SunYunzeng ZouJuying QianJunbo Ge Source Type: research