Gastroesophageal reflux disease, obesity and laparoscopic sleeve gastrectomy: The burning questions.

Gastroesophageal reflux disease, obesity and laparoscopic sleeve gastrectomy: The burning questions. World J Gastroenterol. 2019 Sep 07;25(33):4805-4813 Authors: Bou Daher H, Sharara AI Abstract Obesity is a global health epidemic with considerable economic burden. Surgical solutions have become increasingly popular following technical advances leading to sustained efficacy and reduced risk. Sleeve gastrectomy accounts for almost half of all bariatric surgeries worldwide but concerns regarding its relationship with gastroesophageal reflux disease (GERD) has been a topic of debate. GERD, including erosive esophagitis, is highly prevalent in the obese population. The role of pre-operative endoscopy in bariatric surgery has been controversial. Two schools of thought exist on the matter, one that believes routine upper endoscopy before bariatric surgery is not warranted in the absence of symptoms and another that believes that symptoms are poor predictors of underlying esophageal pathology. This debate is particularly important considering the evidence for the association of laparoscopic sleeve gastrectomy (LSG) with de novo and/or worsening GERD compared to the less popular Roux-en-Y gastric bypass procedure. In this paper, we try to address 3 burning questions regarding the inter-relationship of obesity, GERD, and LSG: (1) What is the prevalence of GERD and erosive esophagitis in obese patients considered for bariatric surgery? (2) Is it necessary to perfo...
Source: World Journal of Gastroenterology - Category: Gastroenterology Authors: Tags: World J Gastroenterol Source Type: research

Related Links:

Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM) Issue: Ahead of print
Source: Clinical Chemistry and Laboratory Medicine - Category: Laboratory Medicine Source Type: research
Authors: Fogato L Abstract Will I actually be ready to face my first surgical on call night? It is the question that haunts every young specialist when, once he has completed his surgical training, he is alone, often by night to face the unpredictable. It is a question of ethical and intellectual honesty to understand that learning curve is something quite different from being transformed from a surgeon by day into a superhero by night. The training gap in Italy and at the same time the typology of patients (obesity, age, gunshot wounds, and stab wounds) who come to our Emergency Departments have exasperated the ne...
Source: Annali Italiani di Chirurgia - Category: Surgery Tags: Ann Ital Chir Source Type: research
CONCLUSIONS: Thanks to the progress made in conservative and interventional treatment and laparoscopic surgery, an increasingly less invasive treatment is proposed in the management of acute diverticulitis. KEY WORDS: Acute diverticulitis, Laparoscopic surgery, Surgical treatment. PMID: 31814600 [PubMed - in process]
Source: Annali Italiani di Chirurgia - Category: Surgery Tags: Ann Ital Chir Source Type: research
CONCLUSIONS: These data impose a closer follow-up of smokers and pre-neoplastic cases and the utility of the broadspectrum polymerase chain reaction assay in laryngeal dysplastic and cancer lesions. This study may allow to develop biomarkers for early detection or recurrence surveillance, to identify therapeutic targets, and to begin individualization of treatment based on the biology of these tumours. KEY WORDS: HPV infection, Larynx, Laryngeal chronic hyperplastic inflammation, Squamous cell carcinoma. PMID: 31814599 [PubMed - in process]
Source: Annali Italiani di Chirurgia - Category: Surgery Tags: Ann Ital Chir Source Type: research
Publication date: Available online 10 December 2019Source: American Journal of Preventive MedicineAuthor(s): Wudeneh M. MulugetaIntroductionLittle is known about the longitudinal trends and factors associated with obesity and overweight among U.S. immigrants and ethnic minorities.MethodsAt a large safety net health system in Massachusetts, 7,973 adults were followed retrospectively for 42.0 months on average from 2011 to 2016. Multivariate analyses were performed to identify factors associated with obesity (BMI ≥30 kg/m2) and overweight (BMI ≥25 kg/m2). Data were collected and analyzed in 2018–2019.ResultsObesi...
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
ConclusionsAn inverse correlation between TL and obesity traits was observed in children with abdominal obesity. Interestingly, we found that baseline TL could predict changes in blood glucose levels.Clinical TrialNCT03147261. Registered 10 May 2017.
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Saying how far consumers need to walk to burn off the calories could change eating habitsLabelling food and drinks with how much walking or running is needed to burn them off could help tackle the obesity crisis, researchers say.While all packaged food must display certain nutritional information, such as calorie content,there is limited evidence that the approach changes what people buy or eat. Meanwhile,waistlines continue to expand.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Obesity Food Health Society UK news Science Nutrition Source Type: news
ConclusionsSeveral risk factors may play a role in evolution of MS. Our results show that smoking status, probably due to chronic vascular and neurotoxic effects of the cigarette components, can affect the brain damage from the early stages of MS. No association was observed with the other explored modifiable risk factors, although an effect due to the small sample size cannot be excluded.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Conclusions: These findings suggest that HON can prevent diet-induced obesity and its associated diseases by regulating the gut microbiota and improving microbial metabolite levels. Moreover, our findings indicate that sex may be an important factor affecting HON activity.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Macrophages are heterogeneous leukocytes regulated in a tissue- and disease-specific context. While in vitro macrophage models have been used to study diseases empirically, a systematic analysis of the transcriptome thereof is lacking. Here, we acquired gene expression data from eight commonly-used in vitro macrophage models to perform a meta-analysis. Specifically, we obtained gene expression data from unstimulated macrophages (M0) and macrophages stimulated with lipopolysaccharides (LPS) for 2–4 h (M-LPSearly), LPS for 24 h (M-LPSlate), LPS and interferon-γ (M-LPS+IFNγ), IFNγ (M-IFNγ), inter...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
More News: Acid Reflux | Bariatric Surgery | Eating Disorders & Weight Management | Endoscopy | Epidemics | Epidemiology | Erosive Esophagitis | Gastrectomy | Gastric Bypass | Gastroenterology | Gastroesophageal Reflux Disease | GERD | Laparoscopy | Obesity | Panendoscopy | Pathology | Schools | Upper Endoscopy