Influenza With Community-Associated Methicillin-Resistant Staphylococcus Aureus Pneumonia.
Influenza With Community-Associated Methicillin-Resistant Staphylococcus Aureus Pneumonia. Am J Med Sci. 2019 Oct;358(4):289-293 Authors: Liu CW, Lin SP, Wang WY, Huang YH Abstract Patients with community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) pneumonia have poor clinical outcomes and high frequency of mortality, especially in patents with postinfluenza infection. Herein, we report a case of community-acquired pneumonia with multiple organ failure in a 51-year-old patient with initial presentation of flu-like symptoms. The influenza rapid test from the specimen of nasopharyngeal swab was positive for type B influenza virus and was confirmed by real-time polymerase chain reaction. Gram stain of bronchoalveolar lavage fluid revealed gram positive cocci in group. Both sputum and blood culture yielded MRSA. We identified the CA-MRSA was staphylococcal cassette chromosome mec type IV strain carried Panton-Valentine leukocidin gene. The patient made a complete recovery following an 8-week treatment course of linezolid and was discharged with independent daily activity. According to our experience, linezolid may be a reasonable treatment choice for CA-MRSA pneumonia due to the virulence of exotoxins. PMID: 31543102 [PubMed - in process]
Condition: Antibiotic Reaction Intervention: Diagnostic Test: urine culture Sponsor: Batool Mutar Completed
THURSDAY, Dec. 12, 2019 -- Few child care center directors report having an influenza vaccine requirement for children and adult caregivers, according to a study published online Dec. 12 in the Journal of the Pediatric Infectious Diseases...
Microbial Drug Resistance, Ahead of Print.
Conclusion: Our results suggest that linezolid as an alternative to vancomycin for the treatment of PNSI caused by MRS with a high rate of efficacy. PMID: 31819809 [PubMed]
Why did the label'healthcare-associated pneumonia'fall out of favor? Dr Holley shares his views.Medscape Critical Care
(Rice University) Motorized molecules activated by light target and drill through highly antibiotic resistant bacteria and kill them within minutes. The molecules can open bacteria to attack by drugs they previously resisted. The strategy could be applied to bacterial infections or diseases on the skin, in the lungs or in the gastrointestinal tract.
(Pediatric Infectious Diseases Society) Influenza can be especially dangerous for children, who are at greater risk for serious complications from the illness, including hospitalization and even death. Yet child care centers in the US rarely require children or the adults who care for them to be vaccinated against flu, according to a new study published in the Journal of the Pediatric Infectious Diseases Society.
Publication date: Available online 10 December 2019Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Alina A. Okhina, Artem D. Rogachev, Olga I. Yarovaya, Mikhail V. Khvostov, Tatyana G. Tolstikova, Andrey G. Pokrovsky, Veniamin A. Khazanov, Nariman F. SalakhutdinovAbstractA method of quantitative determination of camphecene, a new anti-influenza agent, in rat blood plasma based on LC-MS/MS was developed, validated and used to study the distribution of the agent between blood cells and blood plasma. The method was validated according to FDA and EMA recommendations in terms of selectivity, linearity, accur...
ConclusionsThe SE damaged the cell membrane, with the cytoplasm flowing out, disturbed the synthesis of total protein and phosphorus metabolism, and ultimately killed the bacteria.Graphical abstract