Geometric modeling and a retrospective cohort study on the usefulness of fascial tensile reductions in severe keloid surgery

Severe keloids are currently treated with surgical resection followed by radiation. Radiotherapy is essential for preventing recurrences. Fascia tensile reduction suturing may also prevent recurrence. We asked whether superficial fascia tensile reduction with or without deep fascia tensile reduction reduced skin mechanical tension and yielded good outcomes.
Source: Surgery - Category: Surgery Authors: Source Type: research

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Authors: Guedes T, Coelho G, Guimarães J, Costa H Abstract Hypertrophic and keloid scars represent hyperproliferative disorders that can have a significant impact on patients' lives. The authors present the case of a 53 years-old male with a sternal keloid after excision of a sebaceous cyst and multiple sessions of steroid infiltration, with worsening of the lesion. The patient underwent complete excision of the scar and reconstruction with an anterolateral thigh flap - ALT. The postoperative period was uneventful, with no signs of relapse. Keloid scar treatment in sternal area implies a reconstruction with ...
Source: Acta Medica Portuguesa - Category: General Medicine Tags: Acta Med Port Source Type: research
Conditions:   Scar;   Keloid;   Hypertrophic Scar;   Cicatrix Interventions:   Other: Placebo Cream Base Emulsion Moisturizer;   Other: FS2 Emulsion Moisturizer;   Other: Active Comparator Onion Skin Extract Gel (Mederma);   Other: Active Comparator Silicone Gel (Kelo-Cote);   Other: Active Comparator Silicone Gel (Kelo-Cote) + FS2 Emulsion Moisturizer Sponsors:   The Center for Clinical and Cosmetic Research;   BirchBioMed Inc. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Wound Heal;   Scar;   Keloid;   Surgical Wound Interventions:   Other: Vehicle Cream Base Emulsion Moisturizer + Petrolatum;   Other: FS2 Emulsion Moisturizer + Petrolatum Sponsors:   The Center for Clinical and Cosmetic Research;   BirchBioMed Inc. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract Koebner phenomenon refers to the emergence of new psoriatic lesions in the healthy skin regions following an injury/trauma to psoriatic patients. The occurrence of psoriatic lesions at unusual areas of the body regions such as on penis, around eyes and on keloids suggests that the Koebner phenomenon may be responsible for these lesions. A number of agents/triggers have been reported to induce the development of new psoriatic lesions in healthy skin areas and these include, tattooing skin, radiations, skin incision, viral infections, and striae, etc. The different mechanisms that contribute in inducin...
Source: Bioscience Reports - Category: Biomedical Science Authors: Tags: Biosci Rep Source Type: research
CONCLUSIONS: IL-10 was shown to be able to significantly inhibit the proliferation of keloid fibroblasts, which was explicitly and strongly suggestive of its potential therapeutic effect in the management of keloid. PMID: 31696499 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Abstract Following injury, the skin undergoes a wound healing process culminating in the formation of a mature scar. Millions of patients worldwide are left with scars every year as a result of trauma or surgery. Scars can be painful, disfiguring and disabling, yet patients report that clinicians are often dismissive of their concerns, unable to identify pathological scars and unaware of treatment options. The normal wound healing process comprises three overlapping stages: inflammation, proliferation and remodelling. In some patients this process is deranged, resulting in the formation of hypertrophic or keloid s...
Source: British Journal of Hospital Medicine - Category: Internal Medicine Authors: Tags: Br J Hosp Med (Lond) Source Type: research
Publication date: Available online 31 October 2019Source: Hematology/Oncology Clinics of North AmericaAuthor(s): Tony Y. Eng, Mustafa Abugideiri, Tiffany W. Chen, Nicholas Madden, Tiffany Morgan, Daniel Tanenbaum, Narine Wandrey, Sarah Westergaard, Karen Xu
Source: Hematology Oncology Clinics of North America - Category: Hematology Source Type: research
Abstract Keloids are very resistant to treatment in dermatology and plastic surgical practice. The present study aimed to explore the underlying mechanism of botulinum toxin A (BTXA) treated human skin keloid fibroblasts (HSFBs) proving some new insights into keloids treatment. Expression of miR-1587 and miR-2392 were significantly down-regulated in keloid tissues and HSFBs, while the ZEB2 was a target of both and up-regulated in keloid tissues and HSFBs compared with the normal controls. BTXA could significantly increase the expression of miR-1587 and miR-2392 but decrease the expression of ZEB2. BTXA could signi...
Source: Bioscience Reports - Category: Biomedical Science Authors: Tags: Biosci Rep Source Type: research
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Source: Cell Cycle - Category: Cytology Authors: Source Type: research
ConclusionThis meta-analysis showed that TAC  + 5-FU may be the most effective therapy, while verapamil may be a better therapeutic strategy for safety.Level of Evidence IIIThis journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authorswww.springer.com/00266.
Source: Aesthetic Plastic Surgery - Category: Cosmetic Surgery Source Type: research
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