Age-Stratified Risk of Critical Illness in Young Children Presenting to the Emergency Department with Suspected Influenza

To investigate the risk of critical illness by age group among young children without a chronic condition presenting to the emergency department (ED) with suspected influenza.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Original Article Source Type: research

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Condition:   Influenza Intervention:   Behavioral: antibiotic stewardship efforts Sponsor:   Ostfold Hospital Trust Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: 19 November 2019Source: Cell Reports, Volume 29, Issue 8Author(s): Wiebke Hartmann, Marie-Luise Brunn, Nadine Stetter, Nicola Gagliani, Franziska Muscate, Stephanie Stanelle-Bertram, Gülsah Gabriel, Minka BreloerSummaryHelminth parasites infect more than a quarter of the human population and inflict significant changes to the immunological status of their hosts. Here, we analyze the impact of helminth infections on the efficacy of vaccinations using Litomosoides sigmodontis-infected mice. Concurrent helminth infection reduces the quantity and quality of antibody responses to vaccination against seaso...
Source: Cell Reports - Category: Cytology Source Type: research
Publication date: 19 November 2019Source: Cell Reports, Volume 29, Issue 8Author(s): Ying Xu, Ruchao Peng, Wei Zhang, Jianxun Qi, Hao Song, Sheng Liu, Haiyuan Wang, Min Wang, Haixia Xiao, Lifeng Fu, Zheng Fan, Yuhai Bi, Jinghua Yan, Yi Shi, George F. GaoSummarySince 2013, H7N9 avian influenza viruses (AIVs) have caused more than 1,600 human infections, posing a threat to public health. An emerging concern is whether H7N9 AIVs will cause pandemics among humans. Molecular analysis of hemagglutinin (HA), which is a critical determinant of interspecies transmission, shows that the current H7N9 AIVs are still dual-receptor trop...
Source: Cell Reports - Category: Cytology Source Type: research
Publication date: 19 November 2019Source: Cell Reports, Volume 29, Issue 8Author(s): Gloria P. Larson, Vy Tran, Shuǐqìng Yú, Yíngyún Caì, Christina A. Higgins, Danielle M. Smith, Steven F. Baker, Sheli R. Radoshitzky, Jens H. Kuhn, Andrew MehleSummaryAll viruses balance interactions between cellular machinery co-opted to support replication and host factors deployed to halt the infection. We use gene correlation analysis to perform an unbiased screen for host factors involved in influenza A virus (FLUAV) infection. Our screen identifies the cellular factor epidermal growth factor recepto...
Source: Cell Reports - Category: Cytology Source Type: research
In this study, we demonstrate a simple and rapid strategy for visual detection of multiple strains of IAVs (H1 to H16 subtypes) using peptide nucleic acid (PNA) as a biosensor and unmodified gold nanoparticles (AuNPs) as a reporter. The design principle of the assay is based on the color change on account of free PNA-induced aggregation of AuNPs in the presence of non-complementary viral RNA sequence and vice-versa. The assay could detect IAV RNA with a visual limit of detection of 2.3 ng. The quantification of RNA with a considerable accuracy on a simple spectrophotometer was achieved on plotting the PNA-induced colorim...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
Conclusions: In many cases, pediatric AOM was found to constitute a respiratory polymicrobial infection. Multiplex PCR was useful to detect multiple respiratory viruses and bacteria in AOM. To understand intractable AOM, further studies regarding the clinical features of each viral and bacterial coinfection are required.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Original Studies Source Type: research
AbstractPurpose of ReviewThe goal of this review is to evaluate the role of inhibiting the synthesis of lipoproteins when there is no or little residual LDL-receptor function as in patients with homozygous familial hypercholesterolaemia. Lomitapide is administered orally once a day while mipomersen is given by subcutaneous injection once a week. Lomitapide inhibits microsomal triglyceride transfer protein while mipomersen is an antisense oligonucleotide directed against apoB100.Recent FindingsThe pivotal registration trials for lomitapide and mipomersen were published in 2013 and 2010, respectively. More recently published...
Source: Current Atherosclerosis Reports - Category: Cardiology Source Type: research
IL-33 is a member of the IL-1 cytokine family and constitutively expressed in endothelial cells and epithelial cells exposed to stimuli. IL-33 was identified as a ligand of the IL-1 receptor family member ST2L. IL-33 activates group2 innate immune cells, mast cells, eosinophils, basophils, NKT cells, dendritic cells, and neutrophils [1]. IL-33 can enhance the Th2 immune reaction to promote cytokines, and it also functions as a nuclear factor to suppress or enhance NF- κB function [2]. Recent studies showed that IL-33 is involved in anti-viral reactions, such as airway infection with influenza virus or parainfluenza v...
Source: Journal of Dermatological Science - Category: Dermatology Authors: Tags: Letter to the Editor Source Type: research
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Source: Human Vaccines and Immunotherapeutics - Category: Allergy & Immunology Authors: Source Type: research
Scientists fear mass medication of livestock if the UK diverges from EU rules Related items fromOnMedica Doctors can help overcome ‘vaccine hesitancy’ NHS review recommends making childhood vaccination more 'convenient' for parents Point-of-care diagnostics needed to curb antimicrobial resistance Swine flu hits youngest most but mortality greatest in elderly Expert questions US advice on influenza vaccines
Source: OnMedica Latest News - Category: UK Health Source Type: news
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