Novel Target For Developing Drugs That Block The Induction Of Tinnitus

An epilepsy drug shows promise in an animal model at preventing tinnitus from developing after exposure to loud noise, according to a new study by researchers at the University of Pittsburgh School of Medicine. The findings, reported this week in the early online version of the Proceedings of the National Academy of Sciences, reveal for the first time the reason the chronic and sometimes debilitating condition occurs...
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Hearing / Deafness Source Type: news

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ConclusionsMEG played an additional and valuable role in the localisation of operculo-insular epilepsy for patients with a negative MRI finding.
Source: Seizure - Category: Neurology Source Type: research
Publication date: Available online 13 August 2018Source: Epilepsy &BehaviorAuthor(s): María Guadalupe Valle-Dorado, César Emmanuel Santana-Gómez, Sandra Adela Orozco-Suárez, Luisa RochaAbstractSeveral studies indicate that sodium cromoglycate (CG) induces neuroprotective effects in acute neurological conditions. The present study focused on investigating if the use of CG in rats during the post-status epilepticus (post-SE) period reduces the acute and long-term consequences of seizure activity. Our results revealed that animals that received a single dose of CG (50 mg/kg s.c.: subcutaneous...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
We examined correlates of depressive symptoms and suicidal ideation in adults using pooled data from epilepsy self-management studies conducted by sites in the Centers for Disease Control and Prevention (CDC) Research Center's Managing Epilepsy Well (MEW) Network that assessed depression severity with the 9-item Patient Health Questionnaire (PHQ-9). Of the 770 subjects in the analysis (mean age 42.4 ± 13.0 years), the mean total PHQ-9 score was 9.4 ± 6.6 and 334 subjects (43.4%) had moderate to severe depressive symptoms (PHQ-9 ≥ 10). Only ongoing seizures and low education were associated wi...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: Available online 13 August 2018Source: Epilepsy &BehaviorAuthor(s): Chao Zhang, Hongyu Yang, Chang Liu, Guojun Zhang, Nan Chen, Kuncheng LiAbstractThe aims of this study were to investigate the brain network connectivity alterations of intractable unilateral mesial temporal lobe epilepsy (MTLE) with cognitive dysfunction before and after anterior temporal lobectomy (ATL) using resting-state functional magnetic resonance imaging (rs-fMRI) study and to further observe the correlation between the brain network connectivity with cognitive performance. Fourteen patients with unilateral left MTLE before and...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: Available online 13 August 2018Source: Epilepsy &BehaviorAuthor(s): Xiaoxuan Fu, Youhua Wang, Manling Ge, Danhong Wang, Rongguang Gao, Long Wang, Jundan Guo, Hesheng LiuAbstractInterictal spike is a biomarker of epilepsy that can occur frequently between seizures. Its potential effects on brain oscillations, especially on theta rhythm (4–8 Hz) that is related to a variety of cognitive processes, remain controversial. Using local field potentials recorded from patients with temporal lobe epilepsy (TLE), we investigated here the impact of spikes on theta rhythm immediately after spikes and durin...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Cannabidiol, a drug derived from marijuana, was effective at treating patients with treatment-resistant epilepsy.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
Condition:   Healthy Intervention:   Sponsors:   Monell Chemical Senses Center;   National Institute on Deafness and Other Communication Disorders (NIDCD);   Children's Hospital of Philadelphia Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 13 August 2018Source: NeuroImage: ClinicalAuthor(s): Maxime Chamberland, Chantal M.W. Tax, Derek K. JonesAbstractIntroductionSurgical resection is an effective treatment for temporal lobe epilepsy but can result in visual field defects. This could be minimized if surgeons knew the exact location of the anterior part of the optic radiation (OR), the Meyer's loop. To this end, there is increasing prevalence of image-guided surgery using diffusion MRI tractography. Despite considerable effort in developing analysis methods, a wide discrepancy in Meyer's loop reconstructions is observed in th...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
ConclusionsThe underlying pathogenesis of new-onset seizures or epilepsy in recipients of transplantation needs to be further elucidated. In addition, more information is required from prospective studies and research focusing on therapeutic strategies.
Source: Seizure - Category: Neurology Source Type: research
ConclusionIctal nausea/retching/vomiting are most frequently of temporal origin. In contrast to previous studies, our ictal video-EEG data suggests that these signs have no lateralizing value. Thus, video-EEG should be performed and while this clinical sign points to a temporal seizure origin, it does not determine its lateralization.
Source: Seizure - Category: Neurology Source Type: research
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