Novel Target For Developing Drugs That Block The Induction Of Tinnitus
An epilepsy drug shows promise in an animal model at preventing tinnitus from developing after exposure to loud noise, according to a new study by researchers at the University of Pittsburgh School of Medicine. The findings, reported this week in the early online version of the Proceedings of the National Academy of Sciences, reveal for the first time the reason the chronic and sometimes debilitating condition occurs...
The vast majority of women with epilepsy are able to get pregnant with relatively few issues, new research shows.Medscape Medical News
Publication date: Available online 11 December 2018Source: SeizureAuthor(s): Yoo Jin Choi, Jae Yun Jung, Joong Hee Kim, Hyuksool Kwon, Joong Wan Park, Young Ho Kwak, Do Kyun Kim, Jin Hee LeeAbstractPurposeWe performed a large, population-based study to analyze the risk factors of the febrile seizures and the subsequent afebrile epileptic seizures.MethodsRelevant data from children born between 2002-2007 were retrieved from the Korean National Health Insurance Service-National Sample Cohort 2002-2013. Children who did not survive the first five years were excluded from the analysis. The risk factors for febrile seizures wer...
Benton S. Purnell, Roland D. Thijs, Gordon F. Buchanan
Giovanni Pellegrino, Oriano Mecarelli, Patrizia Pulitano, Mario Tombini, Lorenzo Ricci, Jacopo Lanzone, Marianna Brienza, Chiara Davassi, Vincenzo Di Lazzaro, Giovanni Assenza
(University of Iowa Health Care) Starting with human brain tissue from patients with epilepsy, University of Iowa researchers used gene expression profiling and bioinformatics to identify 91 FDA-approved drugs, that may also have potential as anti-epilepsy treatments. Testing showed three of drugs -- a diabetes drug, a hypertension medication, and an antiparasitic therapy -- significantly reduced seizure-like movement in zebrafish.
ConclusionsWe found DP among 14.5% of our drug-resistant epileptic patients with HS. DP patients mostly presented with CPS and had high proportion of ictal and interictal EEG discharges from regional and multi-focal areas. Gliosis and focal cortical dysplasia were the most common pathologies among DP patients. Patients with DP showed a similar behavior to bilateral HS in many features.
The gadget, called NightWatch, could reduce the number of lives lost to Sudden Unexpected Death in Epilepsy (SUDEP), the majority of which occur during the night.
Jianping Wang, Yongxin Li, Ya Wang, Wenhua Huang
Conditions: Stroke; Spinocerebellar Ataxia; Cerebral Stroke; Dysphagia; Dysarthria Interventions: Device: Intermittent Perturbation to Continuous Perturbation; Device: Continuous Perturbation to Intermittent Perturbation Sponsors: University of Florida; National Institute on Deafness and Other Communication Disorders (NIDCD); National Institutes of Health (NIH) Recruiting
ConclusionThis novel service met all criteria of safety and was effective in reducing frequency of seizures. Patients preferred it to conventional services. It should be transferable to other LMICs.