Novel Target For Developing Drugs That Block The Induction Of Tinnitus

An epilepsy drug shows promise in an animal model at preventing tinnitus from developing after exposure to loud noise, according to a new study by researchers at the University of Pittsburgh School of Medicine. The findings, reported this week in the early online version of the Proceedings of the National Academy of Sciences, reveal for the first time the reason the chronic and sometimes debilitating condition occurs...
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Hearing / Deafness Source Type: news

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This study used an operant conditioning animal model to examine the interaction between tinnitus and auditory vigilant attention as well as auditory selective attention. Tinnitus was induced in 90-day-old rats by a unilateral exposure to band-limited noise (120 dB, SPL). Tinnitus testing began 90 days following exposure; afterward animals were divided into 3 groups: Unexposed controls without tinnitus, Exposed without tinnitus, and Exposed with tinnitus. Tinnitus was evident in the vicinity of 20 kHz. Vigilant attention was quantified by the behavioral (operant) response to unpredictable sound transitions signaling changes...
Source: Neuroscience - Category: Neuroscience Source Type: research
AbstractMesial temporal lobe epilepsy (MTLE) associated with hippocampal sclerosis (HS) is the most common form of partial epilepsy. The aim of the present study is to highlight possible and suitable biomarkers that can help in the diagnosis and prognosis of this intractable form of epilepsy. The study was carried out on 30 epileptic patients of both sexes with complex partial seizures, having an age ranging from 4 to 30  years and were selected from the outpatient epilepsy clinic at the Kasr El-Aini Hospital in Cairo, Egypt. Thirty healthy children and young adults, age- and sex-matched to the patients, were included...
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research
Publication date: Available online 18 October 2018Source: Epilepsy &Behavior Case ReportsAuthor(s): Jason Lockrow, Hannah Tully, Russell SanetoAbstractCongenital TORCH infections are a significant cause of epileptic spasms, an infantile epileptic encephalopathy, through disruptions to several pathways in neurodevelopment. Congenital Zika virus has a similar neurotropism to other TORCH agents, and leads to microcephaly, severe neurodevelopmental impairment, and high rates of early onset seizures. Here we report a child with confirmed congenital Zika virus who developed extensor epileptic spasms and hypsarrhythmia associ...
Source: Epilepsy and Behavior Case Reports - Category: Neurology Source Type: research
We report on a girl affected by epileptic seizures treated with levetiracetam for five years. Due to worsening of the seizures, the dosage of this drug was increased and afterwards lowdosage topiramate was initiated. After 12 days from the introduction of topiramate, the girl began to present neurologic signs including limbs rigidity, pain, incoordination and flexed fingers. Gradual withdrawn of the topiramate resulted in progressive resolution of the symptomatology. This clinical episode could represent a probable topiramate-related side effect (Naranjo score 5), never reported before in this form. PMID: 29437013 [Pu...
Source: Epilepsy Curr - Category: Neurology Authors: Tags: Curr Drug Saf Source Type: research
Condition:   Hearing Loss Intervention:   Procedure: FNIRS Observational Sponsor:   University of Michigan Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Jones ML, Morris JT, Mueller JL, Lippincott B, Sweatman WM Abstract Accessibility of telecommunication technologies by people who are deaf or hard of hearing has been a critical issue since the invention of the telephone. As both telephone and hearing-aid technologies have evolved, finding compatible solutions has been an ongoing challenge. This paper uses the findings of a longitudinal study to examine the impact of Federal hearing-aid compatibility (HAC) regulations in resolving this problem. The study ran concurrently with the phase-in of Federal Communications Commission regulations requiring that mobi...
Source: Assistive Technology - Category: Rehabilitation Tags: Assist Technol Source Type: research
Rett Syndrome (RTT) is a complex neurodevelopmental disorder, frequently associated with epilepsy. Despite increasing recognition of the clinical heterogeneity of RTT and its variants (e.g Classical, Hanefeld ...
Source: BMC Pediatrics - Category: Pediatrics Authors: Tags: Research article Source Type: research
Lee Sign language is intentionally designed to allow deaf and dumb communities to convey messages and to connect with society. Unfortunately, learning and practicing sign language is not common among society; hence, this study developed a sign language recognition prototype using the Leap Motion Controller (LMC). Many existing studies have proposed methods for incomplete sign language recognition, whereas this study aimed for full American Sign Language (ASL) recognition, which consists of 26 letters and 10 digits. Most of the ASL letters are static (no movement), but certain ASL letters are dynamic (they require certa...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
Conclusion: It is worth mentioning that the proposed study utilized a single linear feature to predict seizures precisely. Moreover, utilization of single feature encouraged in subsiding system complexity, processing delays, and system latency. PMID: 30332347 [PubMed - as supplied by publisher]
Source: Neurological Research - Category: Neurology Tags: Neurol Res Source Type: research
A new genetic cause of severe, difficult-to-treat childhood epilepsy syndrome has been identified, offering clues to potential medical treatments.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
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