Novel Target For Developing Drugs That Block The Induction Of Tinnitus

An epilepsy drug shows promise in an animal model at preventing tinnitus from developing after exposure to loud noise, according to a new study by researchers at the University of Pittsburgh School of Medicine. The findings, reported this week in the early online version of the Proceedings of the National Academy of Sciences, reveal for the first time the reason the chronic and sometimes debilitating condition occurs...
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Hearing / Deafness Source Type: news

Related Links:

In children with epilepsy, recorded scalp spike ripples are better than spikes at predicting seizure risk, according to new findings.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news
Authors: Lillywhite A, Wolbring G Abstract Disabled people are often the anticipated users of scientific and technological products and processes advanced and enabled by artificial intelligence (AI) and machine learning (ML). Disabled people are also impacted by societal impacts of AI/ML. Many ethical issues are identified within AI/ML as fields and within individual applications of AI/ML. At the same time, problems have been identified in how ethics discourses engage with disabled people. The aim of our scoping review was to better understand to what extent and how the AI/ML focused academic literature engaged wit...
Source: Assistive Technology - Category: Rehabilitation Tags: Assist Technol Source Type: research
Progressive myoclonus epilepsy (PME) comprises a group of rare heterogeneous genetic disorders that are generally manifested as a combination of myoclonic and tonic-clonic seizures with cognitive impairment, ataxia and other cerebellar signs, and other neurologic deficits. They are often encompassed under the broader term "catastrophic epilepsies", which are invariably associated with significant neurological morbidity and often early mortality. This group also include epileptic encephalopathies [1].
Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Source Type: research
If You’re Depressed, Why Bother Getting Up&Ready for the Day?I was recently asked if I had a blog post about why I cared so much about my dress, hair, and appearance despite my depression. What drives me to bother cleaning up when laying in bed while reading news in my PJs is easier to do? Why bother shaving? Why bother showering? Why bother getting up at all?I couldn’t find a specific blog where I addressed this issue, but the pat answer is that my vanity is a super power. Vanity overpowers the darkest, deepest depressions to make sure at least my hair is presentable. Doesn’t that sound superficial? ...
Source: The Splintered Mind by Douglas Cootey - Category: Psychiatry Tags: Depression Family Goodreads Suicide Source Type: blogs
Conclusion: The pitch mismatch was smaller for the perimodiolar electrode array than for the lateral wall electrode array.Audiol Neurotol 2019;24:38 –48
Source: Audiology and Neurotology - Category: Audiology Source Type: research
Hongye Zhao1,2, Tiezheng Zheng1, Xiaohan Yang1, Ming Fan3, Lingling Zhu3, Shuhong Liu3, Liying Wu3 and Changkai Sun1,4* 1Department of Physiology and Key Laboratory of Brain Diseases of Liaoning Province, School of Basic Medical Sciences, Dalian Medical University, Dalian, China 2Department of Physiology, School of Basic Medical Sciences, Qiqihar Medical University, Qiqihar, China 3Department of Brain Protection and Plasticity, Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing, China 4Department of Biomedical Engineering, Faculty of Electronic Information and Electrical Engineerin...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Grand Total EEG Score Can Differentiate Parkinson's Disease From Parkinson-Related Disorders Ela Austria Barcelon1,2*, Takahiko Mukaino1, Jun Yokoyama1, Taira Uehara2, Katsuya Ogata2, Jun-ichi Kira1 and Shozo Tobimatsu2 1Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan2Department of Clinical Neurophysiology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan Background: Semi-quantitative electroencephalogram (EEG) analysis is easy to perform and has been used to differentiate dementias, as well ...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusion The m.10191T>C mutation in the mtDNA of the complex I (CI) subunit of MTND3 results in the substitution of a highly conserved amino acid (p.Ser45Pro) within the ND3 protein, leading to CI dysfunction through impaired enzyme catalysis rather than impaired stability or assembly, causing a broad clinical spectrum of disorders (26). Patients with the m.10191T>C mutation are rare. In the present study, we report on a family of patients with the extremely rare adult-onset Leigh-like syndrome with the m.10191T>C mutation. Including the two patients from our reported family, the m.10191T>C mutation has bee...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusion: Our findings indicate that the genetic test based on WES can be useful in diagnosing SYM1 patients, with particular advantages in preventing the fetus from contacting harmful X-ray through the traditional radiography. The novel pathogenic mutation identified would further expand our understanding of the mutation spectrum of NOG in association with SYM1 disease and provide a guidance on how to determine whether the fetus is affected by SYM1 through the prenatal diagnosis. Introduction Proximal symphalangism (MIM#185800, SYM1) is a rare autosomal dominant bone disorder with principal features of variable ...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
In this study we show that different level of the neuronal activity can trigger Ca2+ dynamics in astrocyte with various spatio-temporal characteristics which can lead to different astrocytic-induced regulatory effects on synaptic transmission. The minimal synaptic activity causes the fast and local Ca2+ elevation in astrocytic process. This small Ca2+ signal triggers the gliotransmission in the active synapse induces localized regulatory astrocytic feedback of the synapse (Figure 6). Increasing frequency of synaptic activity can produce Ca2+ signal which can spread to another astrocytic process (Figure 7) and to the whole ...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
More News: Academies | Audiology | Deafness | Epilepsy | Health | Study | Tinnitus