Reversible neuroinhibition does not require a thermal mechanism

We wish to respond to the recent publication by Darrow et  al. titled “Reversible Neuroinhibition by Focused Ultrasound is mediated by a Thermal Mechanism [1].” Specifically, we wish to alert the larger transcranial Focused Ultrasound Sonication (tFUS) community regarding inducing reversible neuroinhibition without thermal changes. Prior research has clearly demonstrated neuroinhibition without the temperature change suggested by Darrow et al. In a study attempting to suppress regional cortical excitability in rabbits, fMRI BOLD was used to monitor neural activity in the visual cortex after LED light stimulation [2].

Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - September 23, 2019 Category: Neurology Authors: Norman M. Spivak, Mark E. Schafer, Alexander Bystritsky Source Type: research