Antimicrobial stewardship approach: Prevalence of antimicrobial resistant bacteria at a regional hospital in South Africa

Conclusion: The selection of empirical antimicrobial therapy relates not only the institutions or unit-specific antibiogram but also the site of infection. We can further suggest continuing to do surveillance of antibiogram and prevalence of MDR organisms for infection control as well as for empirical therapy, part of the antimicrobial stewardship program based on yearly records to change the local hospital antibiotic policy.
Source: The Journal of Infection in Developing Countries - Category: Infectious Diseases Source Type: research

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(Natural News) Nurses and doctors across America will beg and plead with you to get your flu shot “early” so you can build up immunity to the known mass serial killer called influenza. Yet, most people who die from the flu didn’t really. They died from pneumonia, MRSA superbugs and a crippled immune system caused...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Abstract Patients with community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) pneumonia have poor clinical outcomes and high frequency of mortality, especially in patents with postinfluenza infection. Herein, we report a case of community-acquired pneumonia with multiple organ failure in a 51-year-old patient with initial presentation of flu-like symptoms. The influenza rapid test from the specimen of nasopharyngeal swab was positive for type B influenza virus and was confirmed by real-time polymerase chain reaction. Gram stain of bronchoalveolar lavage fluid revealed gram positive cocci in gro...
Source: The American Journal of the Medical Sciences - Category: General Medicine Authors: Tags: Am J Med Sci Source Type: research
In this study, we investigated the efficacy of antibiotic therapies and the impact of S. aureus alpha-toxin in a model of lethal influenza virus and MRSA coinfection. We demonstrate that antibiotics primarily attenuate alpha-toxin-induced acute lethality, even though both alpha-toxin-dependent and -independent mechanisms significantly contribute to animal mortality after coinfection. Furthermore, we found that the protein synthesis-suppressing antibiotic linezolid has an advantageous therapeutic effect on alpha-toxin-induced lung damage, as measured by protein leak and lactate dehydrogenase (LDH) activity. Importantly, usi...
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Host Response and Inflammation Source Type: research
Conclusion: MCC-IMS is a promising tool for the detection of resistant strains in vitro. More resistant strains will be evaluated and presented.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Respiratory infections Source Type: research
This study aimed to determine which characteristics are associated with certain etiological agents.Methods: Retrospective analysis of community-acquired pneumonia (CAP) cases in adults hospitalized at an University Hospital from January 2013 to December 2015. Patients were stratified according to etiological agent, monthly incidence, demographic characteristics, life styles and comorbidities.Results: Etiological diagnosis was obtained in 22% of 1901 cases. The most common agent was pneumococcus, followed by H. influenza, gram-negative bacilli (GNB), Influenza virus, Legionella, MSSA and MRSA, Moraxella, other bacteria and ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Respiratory infections Source Type: research
We report a case of a 13-year-old female who presented to the Emergency Department with altered mental status and respiratory distress following a treatment course for influenza. She was diagnosed with multifocal pneumonia and developed fulminant respiratory failure requiring ECLS. The causative organism was later found to be Methicillin-Resistant Staphylococcus Aureus (MRSA). She was maintained on ECLS for 49 days and developed secondary complications of lung necrosis, an intrathoracic hematoma, and multiple bronchopleural fistulae. She was managed non-operatively for these complications until she stabilized enough to be ...
Source: Journal of Pediatric Surgery Case Reports - Category: Surgery Source Type: research
Conclusion: Prior respiratory infection, obesity, alcoholism, and old age (>60 years) were observed to be important risk factors for severe CAP. Prospective studies should evaluate effect of weight reduction and cessation of alcohol consumption on recurrences of pneumonia in this population and on the severity of pneumonia.
Source: Lung India - Category: Respiratory Medicine Authors: Source Type: research
Clinically, MRSA VAP is rare. However, MRSA is a common colonizer of respiratory secretions in ventilated adults in ICUs. The classic clinical features of bona fide S. aureus pneumonia are well known from experience with S. aureus pneumonia with influenza. In a pVAP ICU patient, without the clinical findings of S. aureus pneumonia, i.e., otherwise unexplained new high fevers/chills, hemorrhagic tracheobronchitis, elastin fibers in bronchial secretions, hypotension, rapidly cavitation, and thick walled cavities in one/both lungs [1,2].
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Tags: Letter to the Editor Source Type: research
Clinically, meticillin-resistant Staphylococcus aureus (MRSA) ventilator-associated pneumonia (VAP) is rare. However, MRSA is a common colonizer of respiratory secretions in ventilated adults in intensive care units (ICUs). The classic clinical features of bona fide S. aureus pneumonia are well known from experience with S. aureus pneumonia with influenza. In a potential VAP (pVAP) ICU patient without the clinical findings of S. aureus pneumonia (i.e. otherwise unexplained new high fevers/chills, haemorrhagic tracheobronchitis, elastin fibres in bronchial secretions, hypotension, rapid cavitation, and thick-walled cavities...
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Tags: Letter to the Editor Source Type: research
Dr Paul Auwaerter discusses the antimicrobial options for postinfluenza MRSA pneumonia, and makes the case for a universal flu vaccine.Medscape Infectious Diseases
Source: Medscape Infectious Diseases Headlines - Category: Infectious Diseases Tags: Infectious Diseases Commentary Source Type: news
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