Mechanotransduction and uterine blood flow in preeclampsia- The role of mechanosensing Piezo 1 ion channels.

Mechanotransduction and uterine blood flow in preeclampsia- The role of mechanosensing Piezo 1 ion channels. Am J Hypertens. 2019 Sep 23;: Authors: Arishe OO, Ebeigbe AB, Webb RC Abstract There is a large increase in uterine arterial blood flow during normal pregnancy. Structural and cellular adjustments occur in the uterine vasculature during pregnancy to accommodate this increased blood flow through a complex adaptive process that is dependent on multiple coordinated and interactive influences and this process is known as 'vascular remodeling'. The etiology of preeclampsia involves aberrant placentation and vascular remodeling leading to reduced uteroplacental perfusion. The placental ischemia leads to development of hypertension and proteinuria in the mother, intrauterine growth restriction and perinatal death in the fetus. However, the underlying source of the deficient vascular remodeling and the subsequent development of preeclampsia remains to be fully understood. Mechanoreceptors in the vascular system convert mechanical force (shear stress) to biochemical signals and feedback mechanisms. This review focuses on the Piezo 1 channel, a mechanosensitive channel that is sensitive to shear stress in the endothelium, it induces Ca2+ entry which is linked to eNOS activation as the mechanoreceptor responsible for uterine vascular dilatation during pregnancy. Here we describe the downstream signaling pathways involved in this process and the possibility o...
Source: American Journal of Hypertension - Category: Cardiology Authors: Tags: Am J Hypertens Source Type: research

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ConclusionConsidering the results of current study, it is concluded that decreased eNOS expression and oxidative stress could play a role in the pathology of PE seen both in placenta and ultimately in maternal endothelium. However, large studies are necessary to validate these findings to prevent maternal and neonatal morbidity and mortality in Pakistani population.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research
Authors: Paauw ND, Lely AT Abstract Preeclampsia is a pregnancy-specific disorder complicating 2%-8% of pregnancies worldwide and characterized by de novo development of hypertension and proteinuria. Current understanding of the pathophysiology of preeclampsia is limited. A main feature is disrupted spiral artery remodeling in the placenta, which restricts the blood flow to the placenta, which in turn leads to decreased uteroplacental perfusion. Impaired blood flow through the placenta might result in fetal growth restriction and secretion of several factors by the placenta-mainly pro-inflammatory cytokines and ant...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Authors: Wang C, Liu X, Kong D, Qin X, Li Y, Teng X, Huang X Abstract Preeclampsia is a pregnancy-specific disorder of new-onset hypertension and proteinuria after 20 weeks' gestation, often resulting in poor outcome. Previous studies demonstrated that apelin is an endogenous active peptide with visodilation and anti-oxidative stress capabilities. The present study investigated the effects of apelin in a rat model of preeclampsia induced by reduced uterine perfusion pressure (RUPP). Rats with RUPP displayed hypertension and poor pregnancy outcomes, such as decreased fetal and placental weight. Of note, apelin treat...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Introduction: Preeclampsia (PE) is characterized by new onset hypertension in pregnancy and is associated with renal dysfunction, proteinuria and is believed to be initiated by placental ischemia. Mitochondrial dysfunction is an important source of reactive oxygen species (ROS) generation. To better understand the role of mitochondrial dysfunction in hypertension during PE we examined renal mitochondrial expression in the kidney of RUPP rats.Methods: Female Sprague Dawley rats were dived into two groups; normal pregnant (NP) and RUPP rats. On gestational day (GD) 14, RUPP surgery was performed, GD18 carotid catheters were ...
Source: Hypertension - Category: Cardiology Authors: Tags: Poster Abstract Presentations Source Type: research
Objectives: Preeclampsia (PE) is a serious pregnancy-related disease with hypertension and proteinuria manifesting after 20 weeks of gestation. The worldwide prevalence is 3-8%, making it the most common cause of maternal and fetal mortality. PE lacks an effective therapy, and the only “cure” is delivery. We have previously shown that exogenously administered alpha-1-microglobulin (A1M) alleviates PE-like symptoms and the effects of oxidative stress in a dual-placenta perfusion model as well as in pregnant animal PE-models.
Source: Placenta - Category: Reproduction Medicine Authors: Source Type: research
Publication date: July 2017 Source:Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health, Volume 9 Author(s): Baskaran Thilaganathan Human placentation is uniquely associated with physiological remodelling of the spiral arteries by the invading trophoblast to produce a low resistance uterine circulation. Defective placentation is associated with persistence of a high-resistance uterine circulation, impaired placental perfusion and a placental ‘stress’ response leading to the development of preeclampsia (PE). An imbalance of antigenic and antiangiogenic factors have the highest accur...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
Conclusions: These results suggest that there is a seasonal driver for PE, with effects that are not modified by parity, latitude, fetal sex, or smoking. https://doi.org/10.1289/EHP963 Received: 14 August 2016 Revised: 24 January 2017 Accepted: 25 January 2017 Published: 29 June 2017 Address correspondence to C.R. Weinberg, Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 USA. Telephone: (919) 541-4927. Email: weinber2@niehs.nih.gov Supplemental Material is available online (https://doi.org/10.1289/EHP963). The authors declare they h...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
In conclusion, Nam alleviates the PE-like phenotype and FGR in the murine RUPP model. Nam could help treat maternal hypertension and FGR in human PE.
Source: AJP: Renal Physiology - Category: Urology & Nephrology Authors: Tags: RAPID REPORT Source Type: research
Conclusion-Nam alleviates PE-like phenotype and FGR in murine RUPP model. Nam could help treat maternal hypertension and FGR in human PE. PMID: 27927652 [PubMed - as supplied by publisher]
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research
Conclusions AT1-AA are pre-existing prior to the development of placental hypoxia. Surgically induced placental ischaemia does not induce or alter the levels of AT1-AA.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
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