Epilepsy drug could help prevent TINNITUS because it reduces 'hyperactivity' of cells in the ear

Researchers from the University of Pittsburgh found that retigabine prevented the chronic and often debilitating hearing condition from developing after exposure to loud noise in mice.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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ConclusionsUsing clinical diagnosis and behavioral measures of executive function, no differences in functional connectivity were observed among the categories examined. Despite our limited ability to detect small- to medium-sized differences between groups, this work contributes to a growing literature suggesting that traditional diagnostic categories do not define neurobiologically separable groups. Future work is necessary to ascertain the validity of the executive function-based nosology, but current results suggest that nosologies reliant on behavioral data alone may not lead to discovery of neurobiologically distinct categories.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
CONCLUSIONSOur findings indicate that EIMFS may be associated with two types of SB patterns (early-onset and late-onset), which can be distinguished based on the stage of emergence and level of synchrony.
Source: Seizure - Category: Neurology Source Type: research
ConclusionOverall, we found more evidence for a subjective basis rather than a pathophysiological nature for the reported sleep disturbances in PNES subjects. In addition to educating PNES patients on the importance of maintaining good sleep habits, clinicians should address sleep complaints and screen for insomnia, as effective treatments are available and may improve overall health.
Source: Seizure - Category: Neurology Source Type: research
ConclusionBehavioral comorbidities of epilepsy are present very early and can be seen at the time of the diagnosis, however, they do not worsen over time in preschool children. Maternal anxiety should be considered as a risk factor for behavioral problems in preschool children with epilepsy. Assisting children and parents and ensuring necessary guidance and support should be a crucial part of epilepsy treatment initiated as soon as the time of diagnosis.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: March 2019Source: Epilepsy &Behavior, Volume 92Author(s): Charlemagne Vodougnon, Daniel Gérard, Pierre-Emile Bruand, Emilie Auditeau, Farid Boumediene, Inès Yoro Zohoun, Dieudonné Gnonlonfoun, Dismand Houinato, Pierre-Marie PreuxAbstractObjectiveThe main objective of this study was to evaluate the knowledge, attitudes, and practices (KAP) of health sciences students regarding epilepsy at the end of their curriculum in Benin.MethodsWe conducted a cross-sectional survey among medical, pharmacy, nursing, and midwife students in their last year of health sciences training in the Unive...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
In this report, we examine fetal AED exposure effects on learning and memory functions in 221 six-year-old children (including four sets of twins) whose mothers took one of these AEDs during pregnancy. Their performance was compared with that of a national sample of normally developing six year olds from the standardization sample of the Children's Memory Scale (CMS). The major results of this study indicate that the mean performance levels of children exposed to valproate were significantly below that of the children in the normal comparison group across all seven of the CMS Indexes. With one exception, this finding held ...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Conclusions: The main finding of this study is that brain morphology in patients with GGE is significantly different from that in healthy controls. In addition, we found that the different GGE syndromes show distinct structural brain morphology, especially cortical thickness, which can help us understand the pathogenesis of GGE syndromes.Eur Neurol 2018;80:136 –144
Source: European Neurology - Category: Neurology Source Type: research
Publication date: Available online 17 January 2019Source: Stem Cell ReportsAuthor(s): Zoe Noakes, Francesca Keefe, Claudia Tamburini, Claire M. Kelly, Maria Cruz Santos, Stephen B. Dunnett, Adam C. Errington, Meng LiSummaryStriatal interneurons are born in the medial and caudal ganglionic eminences (MGE and CGE) and play an important role in human striatal function and dysfunction in Huntington's disease and dystonia. MGE/CGE-like neural progenitors have been generated from human pluripotent stem cells (hPSCs) for studying cortical interneuron development and cell therapy for epilepsy and other neurodevelopmental disorders...
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
In conclusion, these findings provide novel insights into the mechanism of action by MPH in the treatment of ADHD and further suggest that the long-term effectiveness of the stimulant drug could be limited.
Source: Neurochemistry International - Category: Neuroscience Source Type: research
Purpose of review Recent enthusiasm for cannabinoid drugs for the treatment of chronic pain and some forms of epilepsy, raises the question of whether they could be useful for other disorders associated with abnormal neuronal activity in the brain, such as subjective tinnitus. Indeed, there is evidence to indicate that some tinnitus sufferers self-medicate using Cannabis. The aim of this review is to critically evaluate the available evidence relating to the effects of cannabinoids on tinnitus. Recent findings Despite the fact that cannabinoids have been shown to decrease neuronal hyperactivity in many parts of the br...
Source: Current Opinion in Neurology - Category: Neurology Tags: NEURO-OTOLOGY: Edited by Thomas Brandt Source Type: research
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