Epilepsy drug could help prevent TINNITUS because it reduces 'hyperactivity' of cells in the ear

Researchers from the University of Pittsburgh found that retigabine prevented the chronic and often debilitating hearing condition from developing after exposure to loud noise in mice.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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ConclusionsSimulations provide quantitative insight into the remedial regimens for nonadherent patients, and clinicians should select the optimal regimen based on the status of patients.Graphical abstractThree remedial strategies identified for a 12-year-old and 40-kg patient administered lamotrigine on 125 mg q12h regimen without an inducer or inhibitor when dose was delayed by 10 h. The dark pink shadow represents the distribution of the 5th–95th percentiles of the simulated concentrations in 90% of the virtual subjects, and the light pink shadows represent the distribution of the simulated concentrations outsi...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
This article is part of the Special Issue "Proceedings of the 7th London-Innsbruck Colloquium on Status Epilepticus and Acute Seizures".
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
This article is part of a Special Issue entitled “Status Epilepticus”.This article is part of the Special Issue "Proceedings of the 7th London-Innsbruck Colloquium on Status Epilepticus and Acute Seizures".
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
In conclusion, children with GGE and TLE have significant impairments recognizing emotional expressions on faces. Further research is needed to examine whether underlying FEP impairments relate to social and emotional functioning in children with epilepsy.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Authors: Tamada T, Enatsu R, Suzuki Y, Yokoyama R, Suzuki H, Ochi S, Mikuni N Abstract An electrical cortical stimulation provides important information for functional brain mapping. However, subjective responses (i.e. sensory, visual, and auditory symptoms) are purely detected by patients' descriptions, and may be affected by patients' awareness and intelligence levels. We experienced psychogenic responses in the electrical cortical stimulation of two patients with intractable epilepsy. A sham stimulation was useful for differentiating pseudo-responses from real responses in the electrical cortical stimulation. In...
Source: Neurologia Medico-Chirurgica - Category: Neurosurgery Tags: Neurol Med Chir (Tokyo) Source Type: research
CONCLUSIONS: Benzodiazepine monotherapy is utilized in nearly 1 in 10 patients treated for depression. Adults aged 45 to 65 years, patients prescribed opioids, patients seen by primary care providers, and those with underlying anxiety, epilepsy, or pulmonary disorders are at highest risk. PMID: 31120203 [PubMed - in process]
Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
This study examines the effects of sex and pubertal status on the association between attention-deficit/hyperactivity disorder (ADHD) and depression symptoms in preadolescence through late adolescence. METHODS: Participants were 472 youth from the Multimodal Treatment Study of Children With ADHD. The study sample included 308 youth with DSM-IV ADHD, recruited from 1993 through 1996, and 164 comparison youth who were recruited approximately 2 years later. Self-reported depression symptoms from the Children's Depression Inventory and pubertal status from the Tanner Self-Report Scale were collected, along with combined pa...
Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
Hello, I'm a nursing student here. Ok so I have been doing some research on epilepsy for a presentation in class. On of the subtopics is seizures in relation to alcohol. I have been asking this question as well as trying to search this question and cannot get any solid answer. Every answer is different and everyone claims their answer is correct. The question is, is it possible for someone to have a seizure while drinking alcohol? I am NOT referring to withdrawal because everyone immediately... Alcohol and Seizures?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Neurology Source Type: forums
Publication date: July 2019Source: Epilepsy &Behavior, Volume 96Author(s): Jane B. Allendorfer, Rodolphe Nenert, E. Martina Bebin, Tyler E. Gaston, Leslie E. Grayson, Kathleen A. Hernando, James T. Houston, Barbara Hansen, Jerzy P. SzaflarskiAbstractPatients with treatment-resistant epilepsy (TRE) frequently exhibit memory and attention deficits that contribute to their poor personal and societal outcomes. We studied the effects of adjunct treatment with pharmaceutical grade cannabidiol (CBD) oral solution (Epidiolex®; Greenwich Biosciences, Inc.) on attention control processes related to stimulus conflict resoluti...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Purpose of review Recent enthusiasm for cannabinoid drugs for the treatment of chronic pain and some forms of epilepsy, raises the question of whether they could be useful for other disorders associated with abnormal neuronal activity in the brain, such as subjective tinnitus. Indeed, there is evidence to indicate that some tinnitus sufferers self-medicate using Cannabis. The aim of this review is to critically evaluate the available evidence relating to the effects of cannabinoids on tinnitus. Recent findings Despite the fact that cannabinoids have been shown to decrease neuronal hyperactivity in many parts of the br...
Source: Current Opinion in Neurology - Category: Neurology Tags: NEURO-OTOLOGY: Edited by Thomas Brandt Source Type: research
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