Targeting of EZH2 inhibits epithelial ‑mesenchymal transition in head and neck squamous cell carcinoma via regulating the STAT3/VEGFR2 axis.

In conclusion, we proposed that EZH2 regulates EMT and tumor invasion and metastasis in HNSCC by governing the STAT3/VEGFR2 axis. These findings provide a rationale for developing novel strategies to treat invasive and metastatic HNSCC via targeting the EZH2/STAT3/VEGFR2 pathway. PMID: 31545422 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31545422?dopt=Abstract

Source: International Journal of Oncology - September 17, 2019 Category: Cancer & Oncology Authors: Zhao M, Hu X, Xu Y, Wu C, Chen J, Ren Y, Kong L, Sun S, Zhang L, Jin R, Zhou X Tags: Int J Oncol Source Type: research