Cancer-Related Mutations Identified in Primed and Naive Human Pluripotent Stem Cells.

Cancer-Related Mutations Identified in Primed and Naive Human Pluripotent Stem Cells. Cell Stem Cell. 2019 Sep 11;: Authors: Avior Y, Eggan K, Benvenisty N Abstract Human pluripotent stem cells (hPSCs) are known to harbor chromosomal aberrations, affecting their tumorigenic potential. We established a strategy to identify cancer-related point mutations in hPSCs, detecting recurrent mutations in over 20 genes, alongside those previously detected in p53. Importantly, naive hPSCs harbor, on average, four times more mutations than their primed counterparts, which appear primarily in pathways inhibited during naive conversion. Such cancer-related mutations should be taken into consideration in future applications, especially in clinical contexts. PMID: 31543368 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31543368?dopt=Abstract

Source: Cell Stem Cell - September 10, 2019 Category: Stem Cells Authors: Avior Y, Eggan K, Benvenisty N Tags: Cell Stem Cell Source Type: research