Early Neospora caninum infection dynamics in cattle after inoculation at mid-gestation with high (Nc-Spain7)- or low (Nc-Spain1H)-virulence isolates

AbstractEarlyNeospora caninum infection dynamics were investigated in pregnant heifers intravenously inoculated with PBS (G-Control) or 107 tachyzoites of high (G-NcSpain7)- or low (G-NcSpain1H)-virulence isolates at 110  days of gestation. Serial culling at 10 and 20 days post-infection (dpi) was performed. Fever was detected at 1 dpi in both infected groups (P 
Source: Veterinary Research - Category: Veterinary Research Source Type: research

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Abstract A key drawback to monitoring the emergence and spread of antimalarial drug resistance in sub-Saharan Africa is early detection and containment. Next-generation sequencing methods offer the resolution, sensitivity and scale required to fill this gap by surveilling for molecular markers of drug resistance. We performed targeted sequencing using molecular inversion probes to interrogate five Plasmodium falciparum genes (pfcrt, pfmdr1, pfdhps, pfdhfr and pfk13) implicated in chloroquine, sulphadoxine-pyrimethamine (SP) and artemisinin resistance, in two sites in Ghana. A total of 803 dried blood spots were pr...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
Publication date: January 2020Source: Pathology - Research and Practice, Volume 216, Issue 1Author(s): Hui Wang, Rani KanthanAbstractAmoebiasis, caused by the intestinal protozoan Entamoeba histolytica, though a relatively common parasitic disease in the tropical and subtropical regions, is uncommon in the developed countries. In these countries, as amoebic colitis shares similar clinical symptoms and endoscopic features with inflammatory bowel disease (IBD), these cases can be easily unrecognized and misdiagnosed.In this case report, we discuss the case of an adult patient with invasive intestinal amoebiasis, who was init...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
In this study, the chemiluminescent microparticle immunoassay was used to detectToxoplasma gondii and the seroepidemiology ofToxoplasma gondii was investigated among childbearing women in Qom, Iran. In this study, 202 blood samples were collected from childbearing women for evaluation of toxoplasmosis. Serum samples were isolated to determine anti-Toxoplasma IgM and IgG antibodies. Based on findings, the total prevalence of anti-Toxoplasma antibodies was 134 (66.3%) [95% CI 59.6 –72.5]. In addition, 133 (65.8%) [95% CI 59.1–72.1], 19 (9.4%) [95% CI 6.1–14.2] and 18 (8.9%) [95% CI 5.7–13.6] samples w...
Source: Journal of Parasitic Diseases - Category: Parasitology Source Type: research
Publication date: Available online 27 December 2019Source: Veterinary ParasitologyAuthor(s): Carlos Calvete, José M. González, Luis M. Ferrer, Juan J. Ramos, Delia Lacasta, Ignacio Delgado, Joaquín UriarteAbstractControl of sheep gastrointestinal nematode (GIN) infections mostly relies on the use of anthelmintics. Refugia-based control strategies as targeted selective treatments (TST) can delay anthelmintic resistance development, but the optimal decision criteria for selecting individuals to be treated in subclinical infection scenarios remain unclear. The present study aimed to evaluate the suitabili...
Source: Veterinary Parasitology - Category: Veterinary Research Source Type: research
In this study, 110 T. gondii seropositive at-risk individuals (pregnant women and immunocompromised patients) and 110 seronegative controls were enrolled. The two most used sequences (RE-529 and B1) used and compared for accurate and reliable detection of Toxoplasma gondii in blood samples using UDG-LAMP assay. The detection limit, accuracy, and reliability of UDG-LAMP for the parasite's DNA were also studied. Among 110 studied cases, 39 (35.45%) and 36 (32.7%) were positive for T. gondii DNA with the RE-LAMP and B1-LAMP, respectively. The seronegative cases remained negative for T. gondii DNA with the studied genes. The d...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Seche E, Blaga R Abstract Toxoplasmosis is a zoonotic disease caused by the parasite Toxoplasma gondii. Up to a third of the global human population is estimated to carry a T. gondii infection, which can result in severe complications in immunocompromised individuals and pregnant women. Humans and animals can become infected by ingesting either tissue cysts containing T. gondii bradyzoites, from raw or undercooked meat, or sporulated oocysts from environmental sources. T. gondii oocysts are released in the faeces of cats and other felids, which are the parasite's definitive hosts, leading to environmental contami...
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
We report a case of a pregnant lady who presented with eosinophilia and of how she was worked up to the correct diagnosis. There are only few reported cases of TPE in pregnancy, and there are no reported cases from India. The case also underlines the approach required in these patients to reach the correct diagnosis.
Source: Medical Journal Armed Forces India - Category: General Medicine Source Type: research
Authors: Beltrán Rosel A, Sanjoaquín Conde I, Pérez Muñoz A, Alcalá PM, Marta CB, Irigoyen von Sierakowski A Abstract Strongyloides stercoralis is a parasitic nematode with a worldwide distribution. It can go from an asymptomatic infection to a life-threatening hyperinfection syndrome. Here, we report a case of intestinal obstruction due to S. stercoralis in a pregnant woman. This condition, as well as severe strongyloidiasis in pregnant women, is seldomly reported. In this case, Human Tlymphotropic Virus 1 (HTLV-1) coinfection was confirmed, a well-known risk factor for a more se...
Source: New Microbiologica - Category: Microbiology Tags: New Microbiol Source Type: research
Abstract Artemether-lumefantrine antimalarial efficacy in pregnancy could be compromised by reduced drug exposure. Population-based simulations suggested that therapeutic efficacy would be improved if the treatment duration was increased. We assessed the efficacy, tolerability and pharmacokinetics of an extended 5-day regimen of artemether-lumefantrine compared to the standard 3-day treatment in 48 pregnant women and 48 non-pregnant women with uncomplicated falciparum malaria in an open-label, randomized clinical trial. Babies were assessed at birth, 1, 3, 6 and 12 months. Nonlinear mixed-effects modelling was use...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
ConclusionsThese data are cause for great concern and call for continued surveillance of the efficacy of SP in source and recipient populations, and should be considered when developing treatment policy for imported malaria cases in China and elsewhere.Graphical abstract
Source: International Journal for Parasitology: Drugs and Drug Resistance - Category: Parasitology Source Type: research
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