Inner Workings: Lyme disease vaccines face familiar challenges, both societal and scientific Immunology and Inflammation

Just over 20 years ago, a Lyme disease vaccine called LYMErix was approved for sale in the United States. Researchers designed the vaccine to prevent the transmission of the tick-borne pathogen Borellia burgdorferi, which spurs a bacterial infection that can cause fever, headaches, and joint pain if left untreated. The...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Inner Workings, Front Matter Source Type: research

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EXCLUSIVE: Kelly Brooks, 27, of Hampshire, suffers from chronic Lyme disease - a tick-borne condition that has severe symptoms including agonising joint pain, fatigue and headaches.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Publication date: Available online 24 February 2020Source: Ticks and Tick-borne DiseasesAuthor(s): Cecilie Lerche Nordberg, Jacob Bodilsen, Fredrikke Christie Knudtzen, Merete Storgaard, Christian Brandt, Lothar Wiese, Birgitte Rønde Hansen, Åse Bengård Andersen, Henrik Nielsen, Anne-Mette Lebech, DASGIB study groupAbstractThe goal of this paper is to characterize the clinical presentation, serological results, current antibiotic treatment practice, including compliance with current European guidelines, and outcome in adults with Lyme neuroborreliosis (LNB) diagnosed at department of infectious diseases ...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Conclusions: In children, NB more frequently presented as meningitis, and in adults in the form of Bannwarth’s syndrome. CSF pleocytosis in children with NB was higher than in adults, while the protein concentration in children was lower. Outcomes in children and adults were favorable and did not differ after standard NB treatment.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Original Studies Source Type: research
In 1975, researchers from Yale investigated an epidemic of 51 patients with arthritis who lived near the woodsy town of Lyme, Connecticut. The most common symptom was recurrent attacks of knee swelling. A few had pain in other joints, such as the wrist or ankle. Many had fever, fatigue, and headache. Some remembered a round skin rash before the onset of knee swelling. We now know that Lyme disease is an infection acquired from tick bites, caused by a spiral bacterium named Borrelia burgdorferi. After a tick bite, Borrelia bacteria wriggle through the skin away from the bite site. This leads to a circular red rash, known as...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Arthritis Bones and joints Infectious diseases Source Type: blogs
ConclusionsNon-specific symptoms after tick bite may be caused by uncommon pathogens or co-infection, therefore it should be considered in differential diagnosis after tick bite.
Source: Advances in Medical Sciences - Category: Biomedical Science Source Type: research
For most of us, springtime marks the return of life to a dreary landscape, bringing birdsong, trees in bud, and daffodils in bloom. But if you work for the Centers for Disease Control and Prevention (CDC), the coming of spring means the return of nasty diseases spread by ticks and mosquitoes. The killjoys at CDC celebrated the end of winter with a bummer of a paper showing that infections spread by ticks doubled in the United States from 2004 to 2016. (Tick populations have exploded in recent decades, perhaps due to climate change and loss of biodiversity.) Lyme disease The most common infection spread by ticks in the US i...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Infectious diseases Source Type: blogs
CONCLUSIONS: Our data reported an high percentage of Lyme Disease infection (19%) in non endemic area. The definition of a multidisciplinary working group and a clinical care pathway allowed a better clinical management of Lyme disease cases treated in Sacco Hospital, Milan. PMID: 29600690 [PubMed - as supplied by publisher]
Source: Giornale Italiano di Dermatologia e Venereologia - Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research
Conclusions Non-specific symptoms after tick bite may be caused by uncommon pathogens or co-infection, therefore it should be considered in differential diagnosis after tick bite.
Source: Advances in Medical Sciences - Category: Biomedical Science Source Type: research
CONCLUSIONS: Non-specific symptoms after tick bite may be caused by uncommon pathogens or co-infection, therefore it should be considered in differential diagnosis after tick bite. PMID: 29120859 [PubMed - as supplied by publisher]
Source: Advances in Medical Sciences - Category: Biomedical Science Authors: Tags: Adv Med Sci Source Type: research
“Doesn’t it typically happen during the summer?” asked a worried lady that had walked into my clinic in November with a growing circular rash on her wrist. She was referring, of course, to Lyme disease, that scourge of outdoor enthusiasts. While the peak season for Lyme disease is indeed summer, the ticks that transmit it are active March through December. And, while this may be off-season for the ticks, it is a good time to catch up on how to stay safe in the not-so-distant spring. What is Lyme disease, and how do you treat it? Lyme disease is caused by a bacterium called Borrelia burgdorferi which is sp...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Infectious diseases Prevention Source Type: blogs
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