Antibiotic-potentiating activity of the Phanostenine isolated from Cissampelos sympodialis Eichl.

Antibiotic-potentiating activity of the Phanostenine isolated from Cissampelos sympodialis Eichl. Chem Biodivers. 2019 Sep 23;: Authors: Martins da Costa JG, Cunha WEM, Camilo CJ, Nonato CFA, Mendes JWS, de Carvalho NKG, Coutinho HDM, Menezes IRA, de Lemos TLG, Braz-Filho R, Rodrigues FFG, Matias EFF, Zengin G Abstract Cissampelos sympodialis is well studied and investigated for its antiasthmatic properties, but there are no data in the literature describing antibacterial properties of alkaloids isolated from this botanical species. This work reports the isolation and characterization phanostenine obtained from roots of C. sympodialis and describes for the first time its antimicrobial and antibiotic modulatory properties. Phanostenine was first isolated from Cissampelos sympodialis and its antibacterial activities were determined. Chemical structures of the alkaloid isolate were determined using spectroscopic and chemical analyses. Phanostenine were also tested for their antibacterial activity against standard strains and clinical isolates of Escherichia coli and Staphylococcus aureus. Minimal inhibitory concentration (MIC) was determined in a microdilution assay and for the evaluation of antibiotic resistance-modifying activity, MIC of the antibiotics was determined in the presence or absence of the phanostenine at sub-inhibitory concentrations. The evaluation of antibacterial activity by microdilution assay showed activity for all ...
Source: Chemistry and Biodiversity - Category: Biochemistry Authors: Tags: Chem Biodivers Source Type: research