Monocyte-derived dendritic cells in malaria.
Monocyte-derived dendritic cells in malaria. Curr Opin Microbiol. 2019 Sep 18;52:139-150 Authors: Hirako IC, Assis PA, Galvão-Filho B, Luster AD, Antonelli LR, Gazzinelli RT Abstract The pathogenesis of malaria is a multifactorial syndrome associated with a deleterious inflammatory response that is responsible for many of the clinical manifestations. While dendritic cells (DCs) play a critical role in initiating acquired immunity and host resistance to infection, they also play a pathogenic role in inflammatory diseases. In our recent studies, we found in different rodent malaria models that the monocyte-derived DCs (MO-DCs) become, transiently, a main DC population in spleens and inflamed non-lymphoid organs. These studies suggest that acute infection with Plasmodium berghei promotes the differentiation of splenic monocytes into inflammatory monocytes (iMOs) and thereafter into MO-DCs that play a pathogenic role by promoting inflammation and tissue damage. The recruitment of MO-DCs to the lungs and brain are dependent on expression of CCR4 and CCR5, respectively, and expression of respective chemokine ligands in each organ. Once they reach the target organ the MO-DCs produce the CXCR3 ligands (CXCL9 and CXCL10), recruit CD8+ T cells, and produce toxic metabolites that play an important role in the development of experimental cerebral malaria (ECM) and acute respiratory distress syndrome (ARDS). PMID: 31542508 [PubMed - as supplied by publish...
In this study, we investigate the dynamics of OBs in activated gametocytes of Plasmodium falciparum and Plasmodium yoelii using the female OB-specific marker protein, G377. After activation, female gametocyte OBs migrate to the parasite surface and fuse to form large vesicles beneath the parasite plasma membrane. At the marginal region of female gametocytes, fused vesicles secrete contents by exocytosis into the parasitophorous vacuole space, prior to parasite egress via the break-down of the erythrocyte membrane. This is the first detailed description of how proteins are transported through osmiophilic bodies.
[AIM] Maputo -Mozambique's Coordination Mechanism for the Global Fund to Fight AIDS, Tuberculosis and Malaria on Wednesday reached consensus on the need to create strong and resilient health systems that can respond effectively to the challenges of the Sustainable Development Goals (SDGs).
[FrontPageAfrica] Monrovia -The Liberia Coordinating Mechanism (LCM) of the Global Fund to fight AIDS, TB and Malaria have completed a two-day Country Dialogue for Region 5 counties to provide input to the development of a new joint national TB/HIV funding request for the country. River Gee, Maryland and Grand Kru which are in southeastern Liberia were grouped as region 5 counties to prioritize areas of intervention for the development of a joint TB/HIV funding request for submission to the Global Fund.
[The Conversation Africa] Kenya experienced above-average rainfall since October 2019, causing landslides and deaths. Some rivers burst their banks and dams overflowed for the first time in years.
[Nation] One person has died while 135 others have been treated for Malaria in Elgeyo-Marakwet in the last one week as the disease spreads amidst the lack of drugs in the county.
Conclusion: Due to general lack of awareness towards toxoplasmosis observed among both health workers and pregnant women in Temeke Municipality, we recommend health policy on maternal and child healthcare to address prenatal screening that is aimed at providing early diagnosis for any possible congenital toxoplasmosis as well as diseases that are currently screened in Tanzania such as HIV, syphilis and malaria. Integrating a One Health approach in educating medical professionals and the vulnerable population of pregnant women on the importance of congenital zoonoses will promote awareness and preventive practices towards t...
[East African] The Global Fund, the body that finances the world's HIV, tuberculosis (TB) and malaria programmes, has given Kenya Ksh42 billion ($420 million) to cover the intervening years to 2024.
(Barcelona Institute for Global Health (ISGlobal)) A group of experts led by Regina Rabinovich and Carlos Chaccour from the Barcelona Institute for Global Health (ISGlobal) has published a roadmap to evaluate -- and subsequently implement -- ivermectin as a complementary vector control tool against malaria. The Ivermectin Roadmap, published in the American Journal of Tropical Medicine and Hygiene, includes a foreword signed by Nobel laureate William C. Campbell, co-discoverer of the drug.
Date: Tuesday, 01 28, 2020; Speaker: Ricardo T. Gazzinelli, Professor, University of Massachusetts Medical School; 12735 Twinbrook Pkwy; 2nd Floor Conference Room
Conclusions: This first detailed characterization of novel EXP1-specific T cell epitopes provides important information for future analysis with major histocompatibility complex-multimer technology as well as for immunomonitoring and vaccine design.