Elimination of glutamate using CRRT for 72  h in patients with post-cardiac arrest syndrome: A randomized clinical pilot trial

Glutamine and glutamate are major mediators of secondary brain cell death during post-cardiac arrest syndrome. As there is an equilibrium between brain tissue and plasma concentrations of glutamine and glutamate, their elimination from systemic circulation by extracorporeal blood purification may ultimately lead to reduced secondary cell death in the brain. We hypothesized that systemic glutamine and glutamate can be significantly reduced by continuous venovenous hemodiafiltration (CVVHDF).

Source: Resuscitation - September 22, 2019 Category: Emergency Medicine Authors: Jens Nee, Achim J örres, Alexander Krannich, Christoph Leithner, Tim Schroeder, Anna Lena Munk, Philip Enghard, Christoph Moore, Sonja Steppan, Christian Storm Tags: Clinical paper Source Type: research