Regional epigenetic differentiation of the Z Chromosome between sexes in a female heterogametic system [RESEARCH]

We present evidence consistent with female hypomethylation of MHMs and up-regulation of nearby genes. Therefore, despite little methylation differentiation between sexes, extremely localized DNA methylation differences between male and female chicken Z Chromosomes have evolved and affect expression of nearby regions. Our findings offer new insights into epigenetic regulation of gene expression between sexes in female heterogametic systems.

Source: Genome Research - September 22, 2019 Category: Genetics & Stem Cells Authors: Sun, D., Maney, D. L., Layman, T. S., Chatterjee, P., Yi, S. V. Tags: RESEARCH Source Type: research