Screening for Tuberculosis in Pregnancy

Condition:   Latent Tuberculosis Intervention:   Diagnostic Test: IGRA blood test used as a tool for opt-out screening for latent Tuberculsis infection Sponsors:   Queen Mary University of London;   University College, London;   City, University of London;   Imperial College London Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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ConclusionsTo our knowledge, this study documents the first example of a successful PPP with government partnership in a high-income country to address undocumented migrants ’ lack of access to health services in general and HIV care in particular. In light of the intensification of North-South migration, this Israeli case study could be useful for other countries facing similar challenges. It also has lessons within Israel, as the country grapples with other health p roblems among uninsured communities.
Source: Israel Journal of Health Policy Research - Category: International Medicine & Public Health Source Type: research
In conclusion, the rResult of this study indicates that ATD's had varied degree of toxicity, all the ATDs have considerable adverse effect on the functional competence of male and female gametes, however, with varied degree of toxicity functional potential.Graphical abstract
Source: Environmental Toxicology and Pharmacology - Category: Environmental Health Source Type: research
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Images in Obstetrics Source Type: research
As more women at increased risk for tuberculosis (TB) reactivation immigrate to the United States, perinatal screening and chemoprophylaxis are increasingly important. Interferon-gamma release assays and the tuberculin skin test are acceptable screening tests with the latter supported by more data in pregnancy. Women screening positive should have active TB excluded, and if negative, latent TB is likely. Prophylaxis should be deferred until 3 months postpartum except in those severely immunosuppressed, human immunodeficiency virus positive, or recently exposed. Isoniazid with pyridoxine for 9 months is preferred with reaso...
Source: Clinical Obstetrics and Gynecology - Category: OBGYN Tags: New Antibiotics and Antibiotic Prophylaxis in Obstetrics Source Type: research
Children of mothers who contract a bacterial infection such as pneumonia during pregnancy are significantly more likely to have a psychotic disorder in adulthood compared with those not exposed to infection in utero, according to areport inAJP in Advance.The risk of psychosis in adulthood is even greater when pregnant women have an infection that impacts multiple body systems such as sepsis and is especially high for males.Lead author Younga H. Lee, Ph.D., of Brown University and colleagues said more research with larger sample sizes could help uncover how gestational bacterial infection may directly or indirectly cause ad...
Source: Psychiatr News - Category: Psychiatry Tags: ajp in advance bacterial infection Collaborative Perinatal Project New England Family Study pneumonia psychosis sepsis viral infection Younga Lee Source Type: research
Journal of Perinatology, Published online: 07 October 2019; doi:10.1038/s41372-019-0512-9Impact of human immunodeficiency virus, malaria, and tuberculosis on adverse pregnancy outcomes in the United States
Source: Journal of Perinatology - Category: Perinatology & Neonatology Authors: Source Type: research
AbstractBackgroundTNBC is an aggressive subtype of metastatic breast cancer. Eribulin has been shown to have activity in metastatic TNBC and has enhanced efficacy if TGF- β is downregulated. Additionally, down-regulating TGF-β in the tumor microenvironment may decrease tumor growth and increase responsiveness to checkpoint blockade. Bintrafusp alfa* (M7824) is an innovative first-in-class bifunctional fusion protein composed of the extracellular domain of the TGF-β RII receptor (a TGF-β “trap”) fused to a human IgG1 mAb blocking PD-L1. Therefore the combination of eribulin with bintrafusp al...
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
Roche has won a nod from FDA for a new diagnostic for individual blood donation testing. The Basel-Switzerland-based company’s cobas Babesia test is for use on the cobas 6800/8800 system. Cobas Babesia detects parasites that live in red blood cells. Roche said this test is an important advancement because the Babesia parasite cannot be detected in traditional plasma or serum samples. The test can detect the four-common species of Babesia and employs the new whole blood collection tube, which simplifies Babesia sample preparation by consolidating steps within the tube itself to provide an efficient solutio...
Source: MDDI - Category: Medical Devices Authors: Tags: IVD Regulatory and Compliance Source Type: news
CONCLUSIONS: Although ART scale-up was temporally associated with a decline in TB notification rates, the achieved rates of decline are below those required to achieve the End TB Targets. Additional investments in tuberculosis control should include efforts to promote earlier care seeking and ART initiation among HIV-positive persons. PMID: 31529618 [PubMed - in process]
Source: Journal of the International AIDS Society - Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research
Abstract Pelvic inflammatory disease (PID) is an infection of the upper genital tract occurring predominantly in sexually active young women. Chlamydia trachomatis and Neisseria gonorrhoeae are common causes; however, other cervical, enteric, bacterial vaginosis-associated, and respiratory pathogens, including Mycobacterium tuberculosis, may be involved. PID can be acute, chronic, or subclinical and is often underdiagnosed. Untreated PID can lead to chronic pelvic pain, infertility, ectopic pregnancy, and intra-abdominal infections. The diagnosis is made primarily on clinical suspicion, and empiric treatment is re...
Source: American Family Physician - Category: Primary Care Authors: Tags: Am Fam Physician Source Type: research
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