Pitt team finds mechanism that causes noise-induced tinnitus and drug that can prevent it
(University of Pittsburgh Schools of the Health Sciences) An epilepsy drug shows promise in an animal model at preventing tinnitus from developing after exposure to loud noise, according to a new study by researchers at the University of Pittsburgh School of Medicine. The findings, reported this week in the early online version of the Proceedings of the National Academy of Sciences, reveal for the first time the reason the chronic and sometimes debilitating condition occurs.
Progress in drug development has brought a host of novel agents for the treatment of neurological disorders ranging from multiple sclerosis to chronic pain. However, the treatment of most neurological disorders is still dependent on older medications. This includes medications, such as carbamazepine, with clinical activity across a broad number of disorders. Carbamazepine was first approved in 1963 for the treatment of epilepsy but has been used for treating types of schizophrenia, bipolar disorder, neuropathic pain, tinnitus, and trigeminal neuralgia. Although this agent is safe and effective for many patients, there is a...
Functional MRI (fMRI) offers clues as to which memory lapses in older adults...Read more on AuntMinnie.comRelated Reading: fMRI, machine learning could predict OCD therapy outcomes fMRI shows what makes an angry drunk fMRI, PET could help foresee epileptic seizure issues fMRI helps guide therapy designed to reduce tinnitus MRI shows brain changes after 1 season of youth football
By analyzing resting-state functional MRI (fMRI) brain scans with a machine-learning...Read more on AuntMinnie.comRelated Reading: fMRI shows what makes an angry drunk fMRI, PET could help foresee epileptic seizure issues fMRI helps guide therapy designed to reduce tinnitus
Functional MRI (fMRI) of blood flow in the brain is offering insight into why...Read more on AuntMinnie.comRelated Reading: fMRI, PET could help foresee epileptic seizure issues fMRI helps guide therapy designed to reduce tinnitus
(Wyss Center for Bio and Neuroengineering) The Wyss Center, a non-profit neurotechnology translation organization, has signed a partnership agreement with German medical engineering company, CorTec. The partners will work together on research, design and development of a device for continuous, long-term, monitoring of the brain's electrophysiological signals for clinical diagnostic and therapeutic applications. The planned device will sit on the skull, beneath the skin and has potential uses in epilepsy monitoring, tinnitus regulation through neurofeedback, neuromodulation for dyslexia and other brain circuit disorders.
Researchers have developed a method to integrate functional MR (fMRI) and PET...Read more on AuntMinnie.comRelated Reading: PET/MRI outclasses MRI alone for pelvic cancer recurrence fMRI helps guide therapy designed to reduce tinnitus Researchers resolve PET/MRI issue for epilepsy patients PET/MRI could help diagnose kidney transplant infection
ConclusionsInitial results of DBS studies for diverse neurological disorders are encouraging but larger, controlled, prospective, homogeneous clinical trials are necessary to establish long term safety and effectiveness. The field of neuromodulation continues to evolve and advances in DBS technology, stereotactic techniques, neuroimaging, and DBS programming capabilities are shaping the present and future of DBS research and use in practice.This article is protected by copyright. All rights reserved.
This study compares the prevalence of tinnitus among patients who underwent medial temporal lobe resection, matched controls, and individuals with self-reported epilepsy to determine whether medial temporal lobe removal is associated with tinnitus.
Conclusions: Preliminary evidence suggests that Web-based MBIs may be helpful in alleviating symptom burden that those with physical health conditions can experience, particularly when interventions are tailored for specific symptoms. There was no evidence of differences between synchronous versus asynchronous or facilitated versus self-directed Web-based MBIs. Future investigations of Web-based MBIs should evaluate the effects of program adherence, effects on mindfulness levels, and whether synchronous or asynchronous, or facilitated or self-directed interventions elicit greater improvements.
This article review the evidence that long-term treatment with some antiepileptic drugs (AEDs) [e.g. carbamazepine, phenytoin, valproate, lamotrigine, gabapentin, vigabatrin and oxcarbazepine] (even in therapeutic drug doses) may result in tinnitus, phonophobia, sensorineural hearing loss, dizziness, ataxia, disequilibrium, imbalance, nystagmus, abnormalities in saccadic pursuit eye movements and delayed conduction within the cochlea, auditory nerve and brainstem auditory pathways evidenced by abnormalities in Brainstem auditory evoked potentials and nystagmography recordings indicating auditory and central and/or peripher...