Pitt team finds mechanism that causes noise-induced tinnitus and drug that can prevent it

(University of Pittsburgh Schools of the Health Sciences) An epilepsy drug shows promise in an animal model at preventing tinnitus from developing after exposure to loud noise, according to a new study by researchers at the University of Pittsburgh School of Medicine. The findings, reported this week in the early online version of the Proceedings of the National Academy of Sciences, reveal for the first time the reason the chronic and sometimes debilitating condition occurs.
Source: EurekAlert! - Medicine and Health - Category: Global & Universal Source Type: news

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Publication date: Available online 11 July 2018Source: American Journal of OtolaryngologyAuthor(s): Helena Wichova, Sameer A. Alvi, James Lin, Keith Sale, Christopher Larsen, Hinrich StaeckerAbstractPurposeVagal nerve stimulation in conjunction with sound therapy has been proposed as a treatment for subjective tinnitus. The purpose of this study is to retrospectively review the effect of VNS on perception of tinnitus in epilepsy patients. We explore the incidence of tinnitus and its perceived reduction in patients requiring implantation of VNS for medically refractory seizures.Materials and methodsA phone survey was conduc...
Source: American Journal of Otolaryngology - Category: Endocrinology Source Type: research
Functional MRI (fMRI) has shown that when you get an uplifting feeling from...Read more on AuntMinnie.comRelated Reading: fMRI offers clues about memory loss in older adults fMRI, machine learning could predict OCD therapy outcomes fMRI shows what makes an angry drunk fMRI, PET could help foresee epileptic seizure issues fMRI helps guide therapy designed to reduce tinnitus
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Progress in drug development has brought a host of novel agents for the treatment of neurological disorders ranging from multiple sclerosis to chronic pain. However, the treatment of most neurological disorders is still dependent on older medications. This includes medications, such as carbamazepine, with clinical activity across a broad number of disorders. Carbamazepine was first approved in 1963 for the treatment of epilepsy but has been used for treating types of schizophrenia, bipolar disorder, neuropathic pain, tinnitus, and trigeminal neuralgia. Although this agent is safe and effective for many patients, there is a...
Source: JAMA Neurology - Category: Neurology Source Type: research
Functional MRI (fMRI) offers clues as to which memory lapses in older adults...Read more on AuntMinnie.comRelated Reading: fMRI, machine learning could predict OCD therapy outcomes fMRI shows what makes an angry drunk fMRI, PET could help foresee epileptic seizure issues fMRI helps guide therapy designed to reduce tinnitus MRI shows brain changes after 1 season of youth football
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
By analyzing resting-state functional MRI (fMRI) brain scans with a machine-learning...Read more on AuntMinnie.comRelated Reading: fMRI shows what makes an angry drunk fMRI, PET could help foresee epileptic seizure issues fMRI helps guide therapy designed to reduce tinnitus
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Functional MRI (fMRI) of blood flow in the brain is offering insight into why...Read more on AuntMinnie.comRelated Reading: fMRI, PET could help foresee epileptic seizure issues fMRI helps guide therapy designed to reduce tinnitus
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
(Wyss Center for Bio and Neuroengineering) The Wyss Center, a non-profit neurotechnology translation organization, has signed a partnership agreement with German medical engineering company, CorTec. The partners will work together on research, design and development of a device for continuous, long-term, monitoring of the brain's electrophysiological signals for clinical diagnostic and therapeutic applications. The planned device will sit on the skull, beneath the skin and has potential uses in epilepsy monitoring, tinnitus regulation through neurofeedback, neuromodulation for dyslexia and other brain circuit disorders.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Researchers have developed a method to integrate functional MR (fMRI) and PET...Read more on AuntMinnie.comRelated Reading: PET/MRI outclasses MRI alone for pelvic cancer recurrence fMRI helps guide therapy designed to reduce tinnitus Researchers resolve PET/MRI issue for epilepsy patients PET/MRI could help diagnose kidney transplant infection
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ConclusionsInitial results of DBS studies for diverse neurological disorders are encouraging but larger, controlled, prospective, homogeneous clinical trials are necessary to establish long term safety and effectiveness. The field of neuromodulation continues to evolve and advances in DBS technology, stereotactic techniques, neuroimaging, and DBS programming capabilities are shaping the present and future of DBS research and use in practice.This article is protected by copyright. All rights reserved.
Source: European Journal of Neurology - Category: Neurology Authors: Tags: Reviews Source Type: research
This study compares the prevalence of tinnitus among patients who underwent medial temporal lobe resection, matched controls, and individuals with self-reported epilepsy to determine whether medial temporal lobe removal is associated with tinnitus.
Source: JAMA Neurology - Category: Neurology Source Type: research
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