Cardiac adenylyl cyclase overexpression precipitates and aggravates age-related myocardial dysfunction

ConclusionOur data demonstrated an early and accelerated cardiac remodelling in AC8TG mice, leading to the development of HF and reduced lifespan. Age-related reorganization of cAMP/PKA signalling can accelerate cardiac ageing, partly through GSK3 α/β phosphorylation.
Source: Cardiovascular Research - Category: Cardiology Source Type: research