Synthesis, and molecular docking stimulation of Novel bis-1,4-Dihydropyridines Linked to Aliphatic or Arene Core via Amide or Ester-Amide Linkages.

Synthesis, and molecular docking stimulation of Novel bis-1,4-Dihydropyridines Linked to Aliphatic or Arene Core via Amide or Ester-Amide Linkages.
Mini Rev Med Chem. 2019 Sep 19;:
Authors: Abdella AM, Abdelmoniem AM, Ibrahim NS, El-Hallouty SM, Abdelhamid IA, Elwahy AHM
Abstract
Novel bis(1,4-dihydropyridine-3,5-dicarbonitrile) derivatives linked to arene core via amide or ester-amide linkages were prepared and their structures were confirmed by several spectral tools. The synthesis of novel N,N'-(alkanediyl)bis(2-(2-(3,5-dicyano-2,6-dimethyl-1,4-dihydropyridin-4-yl)phenoxy)acetamide) by an acid-catalyzed condensation of the bis-aldehydes with four equivalents of 3-aminocrotononitrile was reported. The structures of the synthesized compounds were confirmed by the different spectral tools. The molecular docking stimulation studied indicated that, the prepared compounds are promising bioactive molecules.
PMID: 31538896 [PubMed - as supplied by publisher]

Source: Mini Reviews in Medicinal Chemistry - September 18, 2019 Category: Chemistry Authors: Abdella AM, Abdelmoniem AM, Ibrahim NS, El-Hallouty SM, Abdelhamid IA, Elwahy AHM Tags: Mini Rev Med Chem Source Type: research