Elevated miR-615-3p expression predicts adverse clinical outcome and promotes proliferation and migration of prostate cancer cells.

In this study, we investigated the clinical and biological relevance of miR-615-3p in PC. The expression of miR-615-3p was measured in PC tissue specimens from 239 men who underwent radical prostatectomy (RP) and it was investigated if miR-615-3p could predict post-operative biochemical recurrence (BCR). These findings were subsequently validated in three independent RP cohorts (N=222, N=273, and N=387) and functional overexpression studies conducted in PC cells (PC3M). High miR-615-3p expression was significantly associated with BCR in four independent PC patient cohorts (P < 0.05, log-rank test). In addition, high miR-615-3p expression was a significant predictor of PC-specific survival (CSS) in univariate [HR 3.75, P < 0.001] and multivariate analysis after adjustment for the CAPRA-S nomogram [HR 2.66, P = 0.008] in a merged RP cohort (N=734). Moreover, overexpression of miR-615-3p in PC cells (PC3M) significantly increased cell viability, proliferation, apoptosis, and migration. Together, our results suggest that miR-615-3p is a significant predictor of post-operative BCR and CSS and has oncogenic functions in PC cells. PMID: 31539518 [PubMed - as supplied by publisher]
Source: The American Journal of Pathology - Category: Pathology Authors: Tags: Am J Pathol Source Type: research