Loss of nivolumab binding to T cell PD-1 predicts relapse of Hodgkin lymphoma.

Loss of nivolumab binding to T cell PD-1 predicts relapse of Hodgkin lymphoma.
Int J Hematol. 2019 Sep 19;:
Authors: Ogasawara R, Hashimoto D, Sugita J, Yamawaki F, Naka T, Mitsuhashi T, Takahashi S, Miyashita N, Okada K, Onozawa M, Matsuno Y, Teshima T
Abstract
Nivolumab is effective in the treatment of classical Hodgkin lymphoma that relapsed after allogeneic hematopoietic stem cell transplantation (SCT) with the risk of graft-versus-host disease; however, the optimal time and dose of nivolumab administration remain to be investigated. Nivolumab binding to PD-1 masks flowcytometric detection of PD-1 by the anti-PD-1 monoclonal antibody EH12.1. Using this method, we monitored nivolumab binding on T cells after nivolumab treatment in a patient with classical Hodgkin lymphoma relapsed after allogeneic SCT. Nivolumab was effective while prolonged nivolumab binding was evident, but restoration of PD-1 staining predicted tumor relapse. Flowcytometric monitoring of nivolumab binding on T cells could be a promising biomarker for predicting tumor relapse and determining the timing of nivolumab administration.
PMID: 31538325 [PubMed - as supplied by publisher]

Source: International Journal of Hematology - September 18, 2019 Category: Hematology Authors: Ogasawara R, Hashimoto D, Sugita J, Yamawaki F, Naka T, Mitsuhashi T, Takahashi S, Miyashita N, Okada K, Onozawa M, Matsuno Y, Teshima T Tags: Int J Hematol Source Type: research