Innovative approaches for cancer treatment: current perspectives and new challenges.

Innovative approaches for cancer treatment: current perspectives and new challenges. Ecancermedicalscience. 2019;13:961 Authors: Pucci C, Martinelli C, Ciofani G Abstract Every year, cancer is responsible for millions of deaths worldwide and, even though much progress has been achieved in medicine, there are still many issues that must be addressed in order to improve cancer therapy. For this reason, oncological research is putting a lot of effort towards finding new and efficient therapies which can alleviate critical side effects caused by conventional treatments. Different technologies are currently under evaluation in clinical trials or have been already introduced into clinical practice. While nanomedicine is contributing to the development of biocompatible materials both for diagnostic and therapeutic purposes, bioengineering of extracellular vesicles and cells derived from patients has allowed designing ad hoc systems and univocal targeting strategies. In this review, we will provide an in-depth analysis of the most innovative advances in basic and applied cancer research. PMID: 31537986 [PubMed]
Source: Ecancermedicalscience - Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

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Publication date: Available online 21 October 2019Source: Mutation Research/Fundamental and Molecular Mechanisms of MutagenesisAuthor(s): Mohammad-Taghi Bahreyni-Toossi, Elham Dolat, Hashem Khanbabaei, Navid Zafari, Hosein AzimianAbstractGlioblastoma (GBM) is the most lethal type of primary brain tumor. Currently, even with optimal and multimodal cancer therapies, the survival rate of GBM patients remains poor. One reason for inadequate response of GBM tumors to radiotherapy is radioresistance (RR). Thus, there is a critical need for new insights about GBM treatment to increase the chance of treatment. microRNAs (miRNAs) a...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - Category: Cytology Source Type: research
LangmuirDOI: 10.1021/acs.langmuir.9b01891
Source: Langmuir - Category: Chemistry Authors: Source Type: research
Publication date: Available online 20 October 2019Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): Shun Yang, Jie Fan, Shiting Lin, Yaru Wang, Chang LiuAbstractAlthough the biodegradability of silica has been verified, the complete and safe excretion of mesoporous silica nanoparticles (MSNs) from the biological system still impede their clinical translation. Herein, novel pH-responsive biodegradable hollow mesoporous organosilica nanoparticles (PBHMONs) based on pH-responsive silsesquioxane were successfully prepared for efficient anti-cancer drug delivery. pH-responsive cleavable bridges ...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research
Hydrogels are hydrophilic three-dimensional networks able to hold large amount of water and hydrophilic molecules. Magneto-responsive hydrogels comprise of magnetic nanoparticles dispersed in polymeric networks that can be manipulated under external magnetic field. This review aims at (i) giving a brief overview on the evolution of hydrogels until the design and development of magnetic hydrogels; (ii) describing the types of hydrogels and the basic concepts about superparamagnetic iron oxide nanoparticles, as well as the preparation and characterization of magneto-responsive hydrogels; (iii) displaying the relevant applica...
Source: Journal of the Brazilian Chemical Society - Category: Chemistry Source Type: research
nescu Berindan-Neagoe The mitogen-activated protein kinase (MAPK) pathway is an important bridge in the switch from extracellular signals to intracellular responses. Alterations of signaling cascades are found in various diseases, including cancer, as a result of genetic and epigenetic changes. Numerous studies focused on both the homeostatic and the pathologic conduct of MAPK signaling; however, there is still much to be deciphered in terms of regulation and action models in both preclinical and clinical research. MAPK has implications in the response to cancer therapy, particularly the activation of the compensato...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Cancer therapy-induced cognitive impairment adversely affects the quality of life of patients with cancer but cannot be detected by neuropsychological tests.
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AbstractPurposeThe oldest old, described as those aged 85 and older, is a growing cancer population. There are limited studies evaluating the symptoms of the oldest old cancer patient population. Our study aimed to evaluate symptom frequency and clinical symptom change as assessed by the Edmonton Symptom Assessment System (ESAS) of the oldest old ( ≥ 85) compared to older adult (65–84) and general adult (18–64) outpatient cancer patients on initial consult and follow-up visit.MethodsRetrospective review of a total of 441 patients, 200 randomly sampled patients in the general and older adult group and ...
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
Dr Tony Mok of Hong Kong University reviews key studies on non-small cell lung cancer therapies, presented at the 2019 annual meeting of the European Society for Medical Oncology (ESMO).Medscape
Source: Medscape Today Headlines - Category: Consumer Health News Tags: None ReCAP Source Type: news
Publication date: Available online 16 October 2019Source: Materials Science and Engineering: CAuthor(s): Ganesan Raja, Shijie Cao, Deok-Ho Kim, Tae-Jin KimAbstractTitanium dioxide (TiO2) nanoparticles (NPs), first developed in the 1990s, have been applied in numerous biomedical fields such as tissue engineering and therapeutic drug development. In recent years, TiO2-based drug delivery systems have demonstrated the ability to decrease the risk of tumorigenesis and improve cancer therapy. There is increasing research on the origin and effects of pristine and doped TiO2-based nanotherapeutic drugs. However, the detailed mole...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
In this report, we explored data from human RNA-seq and protein–protein interaction (PPI) networks using bioinformatics to investigate the relationship between tumor entropy and aggressiveness. To compare PPI subnetworks of different sizes, we calculated the Shannon entropy associated with vertex connections of differentially expressed genes comparing tumor samples with their paired control tissues. We found that the inhibition of up-regulated connectivity hubs led to a higher reduction of subnetwork entropy compared to that obtained with the inhibition of targets selected at random. Furthermore, these hubs were desc...
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