Examining the Role of Bronchoscopy in Patients with Hematological Malignancies

Examining the Role of Bronchoscopy in Patients with Hematological MalignanciesConference abstracts
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news

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ConclusionsIPA is a potentially lethal complication after HT. Early diagnosis and prompt initiation of aggressive treatment are the cornerstone of better survival.ResumoIntroduçãoA infeção continua a ser uma complicação major nos recipientes para transplante cardíaco (TC), causando cerca de 20% de mortes no primeiro ano após o transplante. Nestes doentes, o Aspergillus species pode levar a várias apresentações clínicas incluindo a aspergilose pulmonar invasiva (API), com uma mortalidade elevada (53% a 78%).ObjetivosEstabelecer as caracter&i...
Source: Revista Portuguesa de Cardiologia - Category: Cardiology Source Type: research
We report an unusual case of a patient with persistent cough and dyspnoea in the context of prior chemoradiotherapy for primary lung cancer who was subsequently found to have invasive tracheobronchial aspergillosis of the distal trachea and proximal of right main bronchus. Invasive tracheobronchial aspergillosis is a rare disease with most reported cases in the literature occurring in immunocompromised hosts. We report an unusual case of a patient with persistent cough and dyspnoea in the context of prior chemoradiotherapy for primary lung cancer. Chest computed tomography (CT) demonstrated an abnormal soft tissue mass sur...
Source: Respirology Case Reports - Category: Respiratory Medicine Authors: Tags: Case Report Source Type: research
Authors: Sakaguchi K, Koga Y, Yagi T, Nakahara T, Todani M, Fujita M, Tsuruta R Abstract Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne infectious disease. A 91-year-old woman was admitted to our intensive-care unit with SFTS, and she developed dyspnea with wheezes 5 days after admission. Bronchoscopy showed scattered white mold in her central airway. An airway tissue biopsy and culture of bronchial lavage fluid revealed fungal hyphae in the necrotic tissue, confirmed as Aspergillus fumigatus. She was thus diagnosed with pseudomembranous aspergillus tracheobronchitis. She had no common risk fact...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Tue, 07/16/2019 - 14:41News blog
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
We report a 9-year- and 6-month-old girl who complained of chronic cough and recurrent wheeze for 2 months. Diagnosis: Bronchialithiasis were found under bronchoscope. Pathologic examination revealed aspergillosis. Interventions: The stone and surrounding granulation tissue were removed using a bronchoscope and the patient was treated with antifungal therapy. Outcomes: The patient was in good general health without any clinical symptoms during the follow-up period. Lessons: Pulmonary Aspergillus infection can cause bronchiolithiasis. Stones were removed under bronchoscope, and anti-Aspergillus therapy was effective.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
CONCLUSIONS: Obstructive ATB is characterised by the excessive production of thick, hyphae-laden mucus, which can obstruct the airway lumen and generate relapsing post-obstructive pneumonias. It is important to consider this diagnosis in immunocompetent patients with recurrent respiratory infections and who show repeated isolation of Aspergillus colonies in the sputum, even in small quantities. PMID: 30503225 [PubMed - as supplied by publisher]
Source: Revista Iberoamericana de Micologia - Category: Biology Authors: Tags: Rev Iberoam Micol Source Type: research
We describe a case of fungal and bacterial infections that developed after BT. Bronchial thermoplasty (BT) is a bronchoscopic treatment for severe asthma. A 35 ‐year‐old woman with uncontrolled severe asthma despite maximal pharmacological treatment underwent BT and started coughing after the first procedure. One month later, during the second BT procedure, there were white ulcerous lesions on the right B9 bronchus. Culture of the bronchial brushing sp ecimen showedAspergillus fumigatus, for which voriconazole was started for treatment. On the third BT procedure, endobronchial mucus sampling demonstratedNocardia spp., ...
Source: Respirology Case Reports - Category: Respiratory Medicine Authors: Tags: Case Report Source Type: research
Introduction: Allergic Bronchopulmonary Aspergillosis(ABPA) most commonly presents with poorly controlled asthma &wheezing. Radiological features include central bronchiectasis &mucus impaction of airways.ABPA presenting as lobar collapse is relatively uncommon.Aim: To study clinical and radiological features of patients with ABPA(non-CF) presenting with lobar collapse.Method: A retrospective analysis of case records of patients diagnosed with ABPA from 2007-2017 at NNUH was done. Clinic letters, radiographic images and laboratory test records were reviewed.Results: A total of 10 patients were identified(n=111,9%)....
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research
Conclusion: Fungal presence and A. fumigatus are detectable by qPCR in patient BAL. Systemically patients displayed varying degrees of antibody reactivity to Aspergillus. Fungal presence significantly correlated with plasma and BAL cytokines indicating an active immune reaction. Further studies are required to assess the role of Aspergillus and other fungal species within the asthmatic lung.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research
We report an initially immunocompetent patient with orbital apex syndrome (OAS) whose presentation suggested giant cell arteritis. Subsequently, metastatic carcinoma was entertained as a cause of OAS until bronchoscopy yielded Blastomyces species. The patient rapidly succumbed with multiorgan failure despite Amphotericin B administration. At post-mortem, Blastomyces co-infection with fungal hyphae in keeping with Aspergillus species was found in cavernous sinus and in infarcted optic nerve. To the best of our knowledge, co-infection with these two organisms in this clinical setting has not been reported.
Source: Saudi Journal of Ophthalmology - Category: Opthalmology Source Type: research
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