A Chinese herbal formula shows beneficial effects on comorbid depression and coronary heart disease based on the philosophy of psycho-cardiology

Publication date: Available online 20 September 2019Source: Journal of Herbal MedicineAuthor(s): Ying Wang, Yu-Jie Liu, Feng-E Li, Zhi Guo, Jun Wang, Comorbid Depression and Coronary Heart Disease Research Group of Cangzhou Central HospitalAbstractDepression is one of the major risk factors for the development, progression and prognosis of coronary heart disease (CHD). Patients with depression and CHD have high mortality and morbidity. Conventional antidepressant therapies achieve limited success in CHD patients. The aim of the present study was to determine the efficacy of a formulation of Chinese herbal medicine called the “Bu Xin Qi decoction (BXQD)” on the symptoms of depression and cardiac prognosis in patients with comorbid depression and CHD. Chinese patients with symptoms that fulfilled the diagnosis criteria were recruited. A total of 280 patients were eligible and randomized to receive escitalopram or BXQD for 8 weeks and follow-up for additional 4 weeks post-treatment. The primary endpoints included episodes of angina pectoris and duration, HAM-D score. Other outcome measures contained the incidence of cardiac events, the levels of high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), adrenaline (NE) and 5-serotonin (5-HT). After 8-week treatment, BXQD significantly decreased episodes and duration of angina pectoris from baseline. HAM-D score was also remarkably decreased in both treatment group. Cardiac events were 11% in the BXQD-treated...
Source: Journal of Herbal Medicine - Category: Complementary Medicine Source Type: research

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There is a strong link between heart disease and depression, both of which are closely related to lifetime stress exposure. Serum/glucocorticoid-regulated kinase 1 (SGK1) is a stress-responsive gene with a pivotal role in both the heart and brain. To determine the role of SGK1 polymorphisms (rs2758151, rs1743963, rs9493857, rs1763509, rs9376026, and rs9389154) in susceptibility to comorbid coronary heart disease (CHD) and depression, we conducted a hospital-based case–control study involving 257 CHD cases (including 69 cases with depression and 188 cases without depression) and 107 controls in a Chinese Han populatio...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Conclusions: Hostility was associated with incidence of CHD among postmenopausal women with diabetes, especially among incident diabetes. These results provide a basis for targeted prevention programs for women with a high level of hostility and diabetes.
Source: Menopause - Category: OBGYN Tags: Original Articles Source Type: research
AbstractAimTo test the hypothetical model of adherence to treatment among patients with coronary disease after percutaneous coronary intervention.DesignA descriptive, explanatory, cross ‐sectional survey.MethodsThe study was conducted in 2013 with 416 patients in five hospitals in Finland. The adherence of patients with chronic disease instrument, the adherence visual analogue scale, the social support for people with coronary heart disease instrument, the EuroQoL five ‐dimensional scale and EuroQoL visual analogue scale were used. The data were analysed using descriptive statistic. The hypothetical model was tested us...
Source: Nursing Open - Category: Nursing Authors: Tags: RESEARCH ARTICLE Source Type: research
Among patients suffering from coronary heart disease (CHD) and comorbid depression, women experience a higher burden compared to men. Little is known on the characteristics that differentiate men and women wit...
Source: BMC Psychiatry - Category: Psychiatry Authors: Tags: Research article Source Type: research
Conclusions: The results of this study demonstrated that more than a half of patients with diabetes had anxiety and/or depression and one third had Type D personality, sustaining that monitoring of emotional state and depression should be included in the therapeutic plan of these patients. New treatment strategies are needed to improve the well-being of diabetic patients with psychological comorbidities. PMID: 31491990 [PubMed - in process]
Source: Medicina (Kaunas) - Category: Universities & Medical Training Authors: Tags: Medicina (Kaunas) Source Type: research
Publication date: Available online 26 August 2019Source: Annals of Physical and Rehabilitation MedicineAuthor(s): Nicole Freene, Margaret McManus, Tarryn Mair, Ren Tan, Rachel DaveyAbstractBackground: International cardiac rehabilitation guidelines recommend that participants meet public health physical activity guidelines. Few studies have objectively measured how much time cardiac rehabilitation participants spend in physical activity and sedentary behaviour, particularly over the long term.Objective: The aim of this study was to objectively assess physical activity and sedentary behaviour of cardiac rehabilitation parti...
Source: Annals of Physical and Rehabilitation Medicine - Category: Rehabilitation Source Type: research
We examined 969 patients, at least 6 months after myocardial infarction or coronary revascularisation. Depression or anxiety was assessed using a standard HADS (Hospital Anxiety and Depression Scale), while QoL by SF-36 (Short-Form-36 Questions) questionnaires. Follow-up was done to assess mortality in incidence of non-fatal cardiovascular event. Results: Both mood disorders were rather frequent; borderline depression or anxiety (HADS score 8-10) had 14.8 or 10.9% of patients, respectively; moderate-to-severe depression or anxiety (HADS score ≥11) had another 8.2 or 6.7% of patients. After adjustment for potentia...
Source: Acta Cardiologica - Category: Cardiology Tags: Acta Cardiol Source Type: research
Abstract Coronary heart disease (CHD) remains a major cause of mortality with a huge economic burden on healthcare worldwide. Here, we conducted a systematic review to investigate the efficacy and safety of Chinese herbal medicine (CHM) for CHD based on high-quality randomized controlled trials (RCTs) and summarized its possible mechanisms according to animal-based researches. 27 eligible studies were identified in eight database searches from inception to June 2018. The methodological quality was assessed using seven-item checklist recommended by Cochrane Collaboration. All the data were analyzed using Rev-Man 5....
Source: Pharmacological Reviews - Category: Drugs & Pharmacology Authors: Tags: Front Pharmacol Source Type: research
AbstractBackgroundFunctional limitations may be more common in middle-aged adults than previously recognized. However, there are few published data on the prevalence of activity limitations, and their association with multimorbidity, among adults 50 to 64  years old.ObjectiveTo describe the prevalence of activity limitations and the association with multimorbidity in middle-aged adults.DesignCross-sectional analysis of US population-based National Health and Nutrition Examination Survey (NHANES) 2011 –2016.ParticipantsThe total number of community-dwelling NHANES participants aged 50 –64 years old is ...
Source: Journal of General Internal Medicine - Category: Internal Medicine Source Type: research
The objective of this study was to investigate cross-sectional and longitudinal associations between declines in sexual activity and function and health outcomes in a large population-based sample of older adults. Data were from 2577 men and 3195 women aged ≥ 50 years participating in the English Longitudinal Study of Ageing. Past-year changes in sexual desire, frequency of sexual activity, and ability to have an erection (men)/become sexually aroused (women) were assessed at baseline by self-completion questionnaire. Health outcomes (self-rated health, limiting long-standing illness, doctor-diagnosed...
Source: Archives of Sexual Behavior - Category: Psychiatry & Psychology Authors: Tags: Arch Sex Behav Source Type: research
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