Asleep at the Switch? Are We Failing to Recognize Obstructive Sleep Apnea in Patients with Atrial Fibrillation and Heart Failure?

Publication date: Available online 20 September 2019Source: Canadian Journal of CardiologyAuthor(s): P. Timothy Pollak, Marcus Povitz
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research

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Obstructive sleep apnea (OSA), a condition in which the soft tissues of the throat relax and narrow the airways during sleep, may raise the risk of developing heart problems after surgery, according toresearch published this week inJAMA. In OSA, breathing stops and starts multiple times during sleep, resulting in snoring, gasping for air, poor sleep quality, morning headaches, daytime fatigue, irritability, and difficulty concentrating.The study, led by Matthew T. V. Chan, Ph.D., M.B.B.S., of the Chinese University of Hong Kong included 1,218 patients aged 45 years or older who had abdominal, vascular, or major orthopedic ...
Source: Psychiatr News - Category: Psychiatry Tags: anesthesia cardiovascular disease heart problems JAMA Matthew Chan obstructive sleep apnea OSA sleep problems surgery Source Type: research
This cohort study assesses the association between unrecognized obstructive sleep apnea (OSA) and 30-day risk of cardiovascular complications (myocardial injury, cardiac death, heart failure, thromboembolism, atrial fibrillation, and stroke) among adults undergoing major noncardiac surgery.
Source: JAMA - Category: General Medicine Source Type: research
Conclusion: These findings limit the possible roles of gene transcriptional changes in previously reported age-dependent pro-arrhythmic electrophysiologial changes observed in Pgc-1β-/- atria to an altered Ca2+-ATPase (Atp2a2) expression. This directly parallels previously reported arrhythmic mechanism associated with p21-activated kinase type 1 deficiency. This could add to contributions from the direct physiological outcomes of mitochondrial dysfunction, whether through reactive oxygen species (ROS) production or altered Ca2+ homeostasis. Introduction Atrial arrhythmias constitute a major public health probl...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Authors: Zhang S, Zhang W, Zhou G Abstract Stroke causes disability and high mortality, while it can be prevented by increasing public awareness of risk factors. The common known risk factors are hypertension, atrial fibrillation, heart failure, smoking, alcohol consumption, low physical activity, overweight and hypercholesterolemia. However, the deep understanding of risk factors is limited. Moreover, more risk factor emerges in recent years. To further increase the awareness of risk factors for stroke prevention, this review indicates the reasonable application of antihypertensive agents according to the age-depe...
Source: Journal of the National Medical Association - Category: General Medicine Tags: J Natl Med Assoc Source Type: research
AbstractPurpose of ReviewThe purpose of this review is to discuss the pathogenesis, clinical manifestations, diagnosis, and treatment, including areas of controversy and uncertainty.Recent FindingsCentral apnea may be due to hypoventilation or to hypocapnia following hyperventilation. The occurrence of central apnea initiates a cascade of events that perpetuates breathing instability, recurrent central apnea, and upper airway narrowing. In fact, breathing instability and upper airway narrowing are key elements of central and obstructive apnea. Clinically, central apnea is noted in association with obstructive sleep apnea, ...
Source: Current Respiratory Care Reports - Category: Respiratory Medicine Source Type: research
Authors: Wojda M, Jurkowski P, Lewandowska A, MierzwiƄska-Nastalska E, Kostrzewa-Janicka J Abstract Obstructive sleep apnea (OSA) is a sleep disorder resulting from the repetitive narrowing and collapse of the upper respiratory tract. The results of previous epidemiological studies confirm a significant impact of OSA on the health situation around the world. Untreated OSA is associated with many adverse health effects, such as hypertension, coronary artery disease, stroke, atrial fibrillation, congestive heart failure, and daytime sleepiness. Excessive mortality of OSA patients, especially in men under 50 yea...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Introduction: We analyse the hypoxia effect on the hepatic profile, glucose metabolism and cardiovascular risk in patients with COPD (Chronic Obstructive Pulmonary Disease), OSA (Obstructive Sleep Apnea) or both.Material and methods: Prospective study with control patients, COPD, OSA or overlap. A blood analysis(inflammatory and metabolic profile) was made. Anthropometric measures and cardiovascular risk factors were collected. We compared demographic and clinical characteristics.Results: 223 patients: COPD 17%, OSA 51%, Overlap 17%, control 14%. 54% overlap, 49% OSA, 34% COPD and 22% control (p
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Sleep and control of breathing Source Type: research
Authors: Al-Khadra Y, Darmoch F, Alkhatib M, Baibars M, Alraies MC Abstract Background: Obstructive sleep apnea (OSA) is a known risk factor for atrial fibrillation (AF) that is principally driven by left atrial enlargement. The impact of hypoventilation caused by obesity-induced hypoventilation syndrome (OHS) on left atrial diameter has not been examined. We investigated the association between OHS and left atrial diameter in obese patients. Methods: We performed a retrospective review of 210 consecutive medical records of patients diagnosed as obese (body mass index [BMI]>30 kg/m2) and as having OHS and OS...
Source: Ochsner Journal - Category: General Medicine Tags: Ochsner J Source Type: research
We examined the relationship between newly diagnosed obstructive sleep apnea (OSA) and incident hospitalized atrial fibrillation (AF) over the subsequent ten years in a large arrhythmia-free cohort. METHODS: Adults referred between 1994 and 2010 to a large academic hospital with suspected OSA who were arrhythmia-free at the time of first diagnostic sleep study were included. Clinical data were linked to provincial health administrative data to define outcome. We used Cox regressions to investigate the relationship between OSA severity as measured by the apnea-hypopnea index (AHI) and degree of nocturnal hypoxemia, and...
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research
The incidence of new-onset atrial fibrillation (NOAF) is increasing both in the Asian populations and Western countries. Several demographic and clinical risk factors were independently associated with NOAF, including ageing, male sex, obesity, obstructive sleep apnea syndrome, hypertension, coronary artery disease, renal dysfunction and heart failure. However, some differences in the incidence of NOAF, the prevalence of some risk factors and lifestyle or environmental conditions may exist between Asian and Western countries.
Source: International Journal of Cardiology - Category: Cardiology Authors: Source Type: research
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