Sarcoid-like Histiocytic Proliferations in Patients With Lymphoma Can Be FDG-avid Concerning for Refractory or Recurrent Disease

Publication date: Available online 30 August 2019Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Zuzan Cayci, Kerem Ozturk, Celalettin Ustun, Aazim K. Omer, Erhan Dincer, Zohar Sachs, Bruce A. Peterson, Michael A. LindenAbstractSarcoidosis has been shown to be associated with increased risk of development of several malignancies including lymphomas. On the other hand, “sarcoid-like reactions” in the absence of other clinical signs of sarcoidosis, have also been described in patients who had been treated with chemotherapy for a wide variety of malignancies. In this article, we report 3 cases who had PET-CT scans concerning for recurrence of the disease after receiving therapy for lymphoma. Upon further investigation, patients were found to have FDG avidity secondary to sarcoid-like reactions, rather than a recurrence of the lymphoma. Although PET imaging is extremely useful in the management of lymphoma, they need to be interpreted with caution. Any FDG avid finding that is suspicious for recurrence need to be thoroughly investigated, likely with histologic confirmation.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research

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Positron emission tomography (PET) has been a very useful tool for staging, managing, and monitoring the response of patients with lymphoma. However, 18F-fluorodeoxyglucose (FDG)-avid lymphadenopathy needs to be carefully evaluated in these patients, given that FDG/PET scans are highly sensitive, but not specific.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Case Report Source Type: research
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Conclusions Conclusions: Differentiation between lymphoma and some lymphadenopathy can be difficult on FDG PET/CT, especially with the tuberculous lymphadenitis. A tumor-specific tracer may be a better choice to solve the problem. Key words: FDG PET/CT; lymphoma; misdiagnosis; lymphadenopathy; tuberculous lymphadeniti s
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: MTA I: Leukemia/Lymphoma/Myeloma Posters Source Type: research
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