Augmentation therapy of N-acetylcysteine for OCD: A meta-analysis of double-blind, randomized, placebo-controlled trials

Publication date: Available online 20 September 2019Source: Journal of Obsessive-Compulsive and Related DisordersAuthor(s): Eliska Noskova, Pavla Stopkova, Jiri Horacek, Antonin SebelaAbstract:Treatment resistance is a barrier to the successful care of patients with OCD. Glutamate modulators such as n-acetylcysteine (NAC) represent a promising new treatment option. To elucidate the current evidence of the efficacy and safety of NAC, we performed a systematic review and meta-analysis of double-blind, randomized, placebo-controlled trials. Primary outcomes were full and partial response rates and a reduction in the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS). Improvement in other clinical scales and the prevalence of various adverse events were also analyzed. Five RCTs (a total of 102 NAC and 100 placebo participants) were found eligible for inclusion. No significant differences in full responses (RR = 1.60; 95% CI = 0.37–6.95, Z = 0.63; p = 0.53), in partial responses (RR = 1.24; 95% CI = 0.76–2.03, Z = 0.85; p = 0.39), and in the reduction in the Y-BOCS (SMD = −0.66; 95% CI = −1.50 – 0.17, Z = 1.56; p = 0.12) were observed between the groups. In general, NAC was well tolerated and no significant differences in the prevalence of adverse events were found between the groups. The current evidence that NAC augmentation is an effective option for treatment resistant OCD is limited.
Source: Journal of Obsessive Compulsive and Related Disorders - Category: Psychiatry Source Type: research

Related Links:

Publication date: Available online 16 October 2019Source: NeuroImage: ClinicalAuthor(s): Wanting Liu, Jun Gan, Jie Fan, Hong Zheng, Sihui Li, Raymond C.K. Chan, Changlian Tan, Xiongzhao ZhuAbstractPoor insight in obsessive-compulsive disorder (OCD) is associated with several adverse clinical outcomes. However, the neurobiological basis of this insight deficit is not clearly understood. The present study thus aimed to investigate associations of cortical thickness, cortical surface area and subcortical volumes with insight in a sample of drug-naïve adults with OCD. Forty-seven OCD patients and 42 healthy controls (HCs)...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
uml;kdağ C Abstract OBJECTIVE: The Obsessive Beliefs Questionnaire (OBQ) is a frequently used instrument in relevant literature for assessment of cognitive biases that play critical roles in appraisal of intrusive experiences in Obsessive Compulsive Disorder (OCD). The questionnaire was initially designed as a 44-item questionnaire, then was shortened to 20 items and lastly was brought down to 9-items. Since so far, only the 44-item version has been available in Turkey, this study aimed to examine psychometric properties of the two shortened OBQ forms in a community sample. METHOD: The study included the dat...
Source: Turkish Journal of Psychiatry - Category: Psychiatry Authors: Tags: Turk Psikiyatri Derg Source Type: research
Authors: Pierce M, Hope HF, Kolade A, Gellatly J, Osam CS, Perchard R, Kosidou K, Dalman C, Morgan V, Di Prinzio P, Abel KM Abstract BACKGROUND: Children of parents with mental disorder face multiple challenges. AIMS: To summarise evidence about parental mental disorder and child physical health. METHOD: We searched seven databases for cohort or case-control studies quantifying associations between parental mental disorders (substance use, psychotic, mood, anxiety, obsessive-compulsive, post-traumatic stress and eating) and offspring physical health. Studies were excluded if: they reported perinatal outcomes only (
Source: The British Journal of Psychiatry for Mental Science - Category: Psychiatry Tags: Br J Psychiatry Source Type: research
This report therefore uses quality assurance data looking into whether sensory processing sensitivity (SPS) affects treatment outcome among patients with OCD. SPS is a personality trait regarding heightened levels of emotional reactivity and deeper cognitive processing of emotional stimuli. Patients received concentrated exposure treatment for obsessive-compulsive disorder (OCD). They were assessed with one of the most widely used questionnaires for measuring SPS, the Highly Sensitive Person Scale (HSPS). Analyses tested whether HSPS scores at pre-treatment affected treatment outcome, and if sensitivity changed from pre-to...
Source: Journal of Obsessive Compulsive and Related Disorders - Category: Psychiatry Source Type: research
Obsessive-compulsive disorder (OCD) is a debilitating neuropsychiatric disorder with a genetic risk component, yet identification of high-confidence risk genes has been challenging. In recent years, risk gene discovery in other complex psychiatric disorders has been achieved by studying rare de novo (DN) coding variants.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Archival Report Source Type: research
Molecular Psychiatry, Published online: 15 October 2019; doi:10.1038/s41380-019-0532-zA population-based family clustering study of tic-related obsessive-compulsive disorder
Source: Molecular Psychiatry - Category: Psychiatry Authors: Source Type: research
Conclusions: In>8 years of observation, most participants experienced a robust and sustained antidepressant response to SCC DBS. News in Context: Ethical issues raised around deep brain stimulation (DBS) research Closing the Circuit: Helen Mayberg’s research could revolutionize depression treatment Expo Day: Neuroenginnering, BPI, Arrowsmith Program &ARPF from SharpBrains
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Health & Wellness Technology antidepressant area-25 brain pacemaker brain stimulation DBS deep-brain-stimulation depression Helen-Mayberg neurosurgical treatment Source Type: blogs
Abstract Over the last two decades, deep brain stimulation (DBS) has gained popularity as a treatment of severe and medically refractory obsessive-compulsive disorder (OCD), often using brain targets informed by historical lesional neurosurgical procedures. Paradoxically, the use of DBS in OCD has led some multidisciplinary teams to revisit the use of lesional procedures, especially anterior capsulotomy (AC), although significant aversion still exists toward the use of lesional neurosurgery for psychiatric disorders. This paper aims to review all literature on the use of AC for OCD to examine its effectiveness and...
Source: Journal of Neurosurgery - Category: Neurosurgery Authors: Tags: J Neurosurg Source Type: research
Are you always in control and always perfectly put together? Are you professionally successful, a great friend, and always showing a happy face to the world?  But what about on the inside? Is there something in the background or in the past that you don’t talk about?  Do you feel disconnected, like no one knows the “real” you? Deep down do you just know something is wrong? Well, you might have “perfectly hidden depression.” Today Gabe speaks with Dr. Margaret Rutherford who has done extensive work on the relationship between perfectionism and depression.  Dr. Rutherford tells u...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Brain and Behavior Depression General Happiness Interview LifeHelper Mental Health and Wellness Perfectionism Personality Podcast Psychiatry Psychology Research Self-Esteem Self-Help The Psych Central Show Trauma Source Type: blogs
This cross-sectional study assesses whether deficits in goal-directed planning are better identified by self-reported compulsivity or a diagnosis of obsessive-compulsive disorder.
Source: JAMA Psychiatry - Category: Psychiatry Source Type: research
More News: Acetylcysteine | Obsessive Compulsive Disorder | Psychiatry | Yale