HWDCNN: Multi-class recognition in breast histopathology with Haar wavelet decomposed image based convolution neural network

Publication date: Available online 20 September 2019Source: Biocybernetics and Biomedical EngineeringAuthor(s): Tasleem Kausar, MingJiang Wang, Muhammad Idrees, Yun LuAbstractAmong the predominant cancers, breast cancer is one of the main causes of cancer deaths impacting women worldwide. However, breast cancer classification is challenging due to numerous morphological and textural variations that appeared in intra-class images. Also, the direct processing of high resolution histological images is uneconomical in terms of GPU memory. In the present study, we have proposed a new approach for breast histopathological image classification that uses a deep convolution neural network (CNN) with wavelet decomposed images. The original microscopic image patches of 2048 × 1536 × 3 pixels are decomposed into 512 × 384 × 3 using 2-level Haar wavelet and subsequently used in proposed CNN model. The image decomposition step considerably reduces convolution time in deep CNNs and computational resources, without any performance downgrade. The CNN model extracts the deep features from Haar wavelet decomposed images and incorporates multi-scale discriminant features for precise prognostication of class labels. This paper also solves the demand for massive histopathology dataset by means of transfer learning and data augmentation techniques. The efficacy of proposed approach is corroborated on two publicly availa...
Source: Biocybernetics and Biomedical Engineering - Category: Biomedical Engineering Source Type: research

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Objectives The goals of this study were to compare the efficacy of the new manganese-based magnetic resonance imaging (MRI) contrast agent Mn-PyC3A to the commercial gadolinium-based agents Gd-DOTA and to Gd-EOB-DTPA to detect tumors in murine models of breast cancer and metastatic liver disease, respectively, and to quantify the fractional excretion and elimination of Mn-PyC3A in rats. Methods T1-weighted contrast-enhanced MRI with 0.1 mmol/kg Mn-PyC3A was compared with 0.1 mmol/kg Gd-DOTA in a breast cancer mouse model (n = 8) and to 0.025 mmol/kg Gd-EOB-DTPA in a liver metastasis mouse model (n = 6). The fractional...
Source: Investigative Radiology - Category: Radiology Tags: Original Articles Source Type: research
It's an extremely rare form of cancer in men, and male breast cancer accounts for just 1% of all breast cancer cases, said Dr. Siddhartha Yadav, a hematology-oncology fellow with the Mayo Clinic in Rochester, Minn.
Source: WebMD Health - Category: Consumer Health News Source Type: news
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Authors: Fedele P, Sanna V, Fancellu A, Cinieri S Abstract Introduction: The dysregulation of cell cycle control can lead to cancer development. In breast cancer, cyclin D, CDK 4,6 and the retinoblastoma protein play a central role in the control of cell proliferation, in crosstalk with the estrogen receptor and Her2 pathways. Although the mechanisms by which the CDK4/6 complex is involved in the control of cell growth in triple negative breast cancer (TNBC) are still unclear, some TNBCs might be sensitive to CDK4/6 inhibitors. Areas covered: The authors provide an overview of the treatments that target cell cycle ...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
Publication date: Available online 14 October 2019Source: Hematology/Oncology and Stem Cell TherapyAuthor(s): Jonathan T. Kapke, Robert J. Schneidewend, Zeeshan A. Jawa, Chiang-Ching Huang, Jennifer M. Connelly, Christopher R. Chitambar
Source: Hematology Oncology and Stem Cell Therapy - Category: Cancer & Oncology Source Type: research
This study tested the hypothesis that vascular endothelial growth factor A and vascular endothelial growth factor receptor 2 contribute to bone cancer pain regulation associated with spinal central sensitization.Methods This study was performed on female rats using a metastatic breast cancer bone pain model. Nociceptive behaviors were evaluated by mechanical allodynia, thermal hyperalgesia, spontaneous pain, and CatWalk gait analysis. Expression levels were measured by real-time quantitative polymerase chain reaction, western blot, and immunofluorescence analysis. Excitatory synaptic transmission was detected by whole-cell...
Source: Anesthesiology - Category: Anesthesiology Source Type: research
Condition:   Primary Breast Cancer Interventions:   Drug: Paclitaxel;   Drug: Docetaxel;   Drug: Cyclophosphamide;   Drug: epirubicin;   Drug: 5-fluorouracil Sponsor:   Fudan University Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Breast Cancer Female Intervention:   Drug: Pyrotinib Sponsor:   RenJi Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
TUESDAY, Oct. 15, 2019 -- Beyonce Knowles'father first suspected something was wrong when he noticed a dot of blood that kept appearing on his shirts and bedsheets. " Imagine a piece of white paper and you took a red pen and just put a dot, " Mathew...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
We present our experience performing single port access total laparoscopic hysterectomy and bilateral salpingo-oophorectomy (SPA-TLH BSO) on a woman after TRAM surgery.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: Virtual Poster Session 2: Laparoscopy (1:00 PM – 1:10 PM) 1:00 PM: STATION N Source Type: research
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