Molecules, Vol. 24, Pages 3434: Hechtia glomerata Zucc: Phytochemistry and Activity of Its Extracts and Major Constituents Against Resistant Bacteria
Molecules, Vol. 24, Pages 3434: Hechtia glomerata Zucc: Phytochemistry and Activity of Its Extracts and Major Constituents Against Resistant Bacteria
Molecules doi: 10.3390/molecules24193434
Authors:
Tommaso Stefani
Elvira Garza-González
Verónica M. Rivas-Galindo
María Yolanda Rios
Laura Alvarez
María del Rayo Camacho-Corona
Hechtia glomerata Zucc. is used both as a source of food and in ethnomedicine to treat various diseases derived from bacterial infections such as bronchitis, laryngitis, nephritis, whooping cough, urethritis, and sepsis. There are no previous reports about its chemistry and biological activities. Therefore, the aims of this study were to identify components from organic and aqueous extracts of H. glomerata and test the extracts and major isolate compounds against resistant bacteria. Hexane, CHCl3/MeOH, and aqueous extracts were prepared and analyzed by different chromatographic techniques. Structural elucidation was carried out by NMR spectroscopy and X-ray diffraction. The antibacterial activities of extracts, phytochemicals, and semisynthetic derivatives against resistant bacteria were determined by the broth micro-dilution method. From the hexane extract nonacosane (1), hexatriacontanyl stearate (2), hexacosanol (3), oleic acid (4), and β-sitosterol (5) were isolated and characterized. From the CHCl3/MeOH extract, p-coumaric acid (6), margaric acid (7), caffeic acid (8), daucosterol (9), and potassium chloride (10) we...
Source: Molecules - Category: Chemistry Authors: Tommaso Stefani Elvira Garza-Gonz ález Ver ónica M. Rivas-Galindo Mar ía Yolanda Rios Laura Alvarez Mar ía del Rayo Camacho-Corona Tags: Article Source Type: research
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