Synthesis and structural characterization of carbosilane ruthenium(II) metallodendrons containing cymene units

Publication date: Available online 19 September 2019Source: Journal of Organometallic ChemistryAuthor(s): Marta Maroto-Diaz, Natalia Sanz del Olmo, Sandra Garcia-Gallego, Rafael Gómez, Paula Ortega, F. Javier de la MataAbstractThe development of heterofunctional carbosilane dendrons with Schiff base ligands in the focal point and allyl or dimethylamino groups in their periphery was achieved. The presence of donor atoms with coordinative capacity enabled the synthesis of ruthenium(II) metallodendrons with cymene units. Depending on the Schiff base ligand present at the focal point of the dendrons, the functionalization of these systems with dimethylamino groups improved the solubility with respect to their analogues with allyl groups, obtaining systems soluble in aqueous medium. The presence of chelate ligands enhanced the stability of the final compounds.This discovery is a starting point to accomplish stable metallodendrons that in future could be tested as possible anticancer agents.Graphical abstract

Source: Journal of Organometallic Chemistry - September 21, 2019 Category: Chemistry Source Type: research