Endogenous Specialized Proresolving Mediator Profiles in a Novel Experimental Model of Lymphatic Obstruction and Intestinal Inflammation in African Green Monkeys

Changes in the intestinal lymphatic vascular system, such as lymphatic obstruction, are characteristic features of inflammatory bowel diseases. The lymphatic vasculature forms a conduit to enable resolution of inflammation; this process is driven by specialized endogenous proresolving mediators (SPMs). To evaluate contributions of lymphatic obstruction to intestinal inflammation and to study profiles of SPMs, we generated a novel animal model of lymphatic obstruction using African green monkeys.

Source: American Journal of Pathology - September 21, 2019 Category: Pathology Authors: Felix Becker, Emily Romero, Jason Goetzmann, Dana L. Hasselschwert, Beth Dray, John Vanchiere, Jane Fontenot, J. Winny Yun, Paul C. Norris, Luke White, Melany Musso, Charles N. Serhan, J. Steven Alexander, Felicity N.E. Gavins Tags: Regular article Source Type: research