TLI in pediatric patients

AbstractPurposeHematopoietic progenitor cell transplantation (HSCT) is a procedure used in different hematological diseases as part of the curative treatment, so the investigators propose a system of conditioning of reduced intensity based on total lymphoid irradiation (TLI) as an alternative to the classic total body irradiation (TBI) followed by haploidentical transplantation in patients compatible with a single HLA haplotype, as an alternative to patients who do not have an HLA compatible donor.Materials and methodsA cohort of 25 patients with hematological disease underwent haploidentical HSCT from February 2015 to May 2018, conditioned with TLI from day − 10 (2–4 days of treatment) followed by thiotepa (5 mg/kg/12 h) and melphalan (70 mg/m2/day) prior to HSCT and prophylaxis with ciclosporin (1.5  mg/kg/12 h). 2 Gy/fraction was administered to complete 8 Gy with IMRT and VMAT technique.Results12% rejection of the transplant was obtained with acute GVHD  
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research

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Condition:   Systemic Scleroderma Interventions:   Procedure: Allogeneic Hematopoietic Stem Cell Transplantation;   Drug: Cyclophosphamide;   Radiation: Intensity-Modulated Radiation Therapy;   Procedure: Total-Body Irradiation Sponsors:   City of Hope Medical Center;   National Cancer Institute (NCI) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Acute Leukemia;   Myelodysplastic Syndrome Interventions:   Procedure: Hematopoietic Cell Transplantation;   Radiation: Intensity-Modulated Radiation Therapy;   Radiation: Tomotherapy;   Radiation: Total-Body Irradiation;   Radiation: Volume Modulated Arc Therapy Sponsors:   City of Hope Medical Center;   National Cancer Institute (NCI) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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