TLI in pediatric patients

AbstractPurposeHematopoietic progenitor cell transplantation (HSCT) is a procedure used in different hematological diseases as part of the curative treatment, so the investigators propose a system of conditioning of reduced intensity based on total lymphoid irradiation (TLI) as an alternative to the classic total body irradiation (TBI) followed by haploidentical transplantation in patients compatible with a single HLA haplotype, as an alternative to patients who do not have an HLA compatible donor.Materials and methodsA cohort of 25 patients with hematological disease underwent haploidentical HSCT from February 2015 to May 2018, conditioned with TLI from day − 10 (2–4 days of treatment) followed by thiotepa (5 mg/kg/12 h) and melphalan (70 mg/m2/day) prior to HSCT and prophylaxis with ciclosporin (1.5  mg/kg/12 h). 2 Gy/fraction was administered to complete 8 Gy with IMRT and VMAT technique.Results12% rejection of the transplant was obtained with acute GVHD  
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research

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Intermediate and long term pulmonary, renal, thyroid, and cataract toxicities are reported in 142 patients after total marrow irradiation (TMI). Mean lung dose of 8 Gy or less is associated with a significant decrease in pulmonary toxicity. IMRT delivery of TMI reduces organ doses and toxicities compared to conventional TBI. Further evaluation of IMRT to deliver TMI, TMLI and organ sparing conformal TBI is warranted.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research
ConclusionMesenteric involvement of DLBCL can be successfully targeted with localized ISRT fields using IMRT and daily CT-image guidance.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
Authors: Lin Y, Kong F, Li H, Xu D, Jia F, Zhang X, Wang B, Li G Abstract The present study aimed to investigate the variations in target volume, clinical reaction and transplantation effects of helical tomotherapy (HT)‑total body irradiation (TBI), HT‑total marrow and lymphatic irradiation (TMLI), intensity modulated radiotherapy (IMRT)‑TBI and IMRT‑TMLI within patients with acute lymphoblastic leukemia (ALL). A total of 18 patients with ALL were treated with the four aforementioned radiotherapy plans prior to hematopoietic stem cell transplantation. A planned prescribed dose of 12 Gy/6 Freq...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Extranodal natural killer/T-cell lymphoma, nasal type (ENKL) is a subtype of mature T- and natural killer cell lymphomas characterized by its association with Epstein-Barr virus and extranodal involvement. Although there is geographic variance in the frequency of ENKL, its clinical features are similar between Western countries and endemic areas, such as East Asia. Anthracycline-containing chemotherapy is not recommended to treat ENKL. No standard treatment has been established based on the results of randomized controlled trials. In patients with localized disease, radiotherapy is a core component of the recommended first...
Source: Blood - Category: Hematology Authors: Tags: Lymphoid Neoplasia, Review Articles Source Type: research
Authors: Yang L, Zhang X, Lv X, Yu H Abstract Radiotherapy and surgery are important radical treatment options for cervical cancer, but the presence of a pelvic kidney complicates the situation. Fine radiation technique can help avoiding side effects. Radiation to the modified pelvis using intensity modulated radiotherapy (IMRT) followed by brachytherapy, while avoiding the renal allograft is technically feasible which ensures adequate target volume and reduces side effects. Here, the authors report a 45-year-old patient with invasive cervical cancer with a pelvic kidney who was treated by pelvic IMRT in combinatio...
Source: European Journal of Gynaecological Oncology - Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research
Introduction: Radiation therapy (RT) is an effective modality in treating Hodgkin Lymphoma (HL), and pts not receiving prior RT routinely received a radiation-based conditioning regimen w/ ASCT if all sites of nodal disease could fit into a radiation field. We aimed to determine the toxicity impact of RT [intensity-modulated radiation therapy (IMRT)&total lymphocyte irradiation (TLI)] after HDT-ASCT.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
High dose melphalan at 200  mg/m2 (Mel200) followed by autologous stem cell transplant (ASCT) improves progression free survival in patients with multiple myeloma (MM) but is not curative. Enhancing the anti-myeloma effect of pre-transplant conditioning without increasing toxicity is therefore an important goal. With this r ationale, intensity modulated radiation therapy (IMRT) can be used to deliver a high dose of radiation to the bone marrow (total marrow irradiation, TMI) while sparing other organs.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
The objective of the study was to analyze the efficacy and feasibility of intensity-modulated radiation therapy (IMRT) for prostate cancer in renal transplant recipients (RTRs).
Source: Transplantation Proceedings - Category: Transplant Surgery Authors: Tags: 14th Congress of the Asian Society of Transplantation Source Type: research
In this study, we investigated ABMSC transplantation as a treatment for acute radiation enteritis. We developed a dog model of acute radiation enteritis using abdominal intensity-modulated radiation therapy in a single X-ray dose of 14 Gy. ABMSCs were cultured in vitro, identified via immunofluorescence and flow cytometry, and double labeled with CM-Dil and superparamagnetic iron oxide (SPIO) before transplantation, which took place 48 hours after abdominal irradiation in a single fraction. The dog model of acute radiation enteritis was transplanted with cultured ABMSCs labeled with CM-Dil and SPIO into the ...
Source: Translational Research : the journal of laboratory and clinical medicine - Category: Laboratory Medicine Authors: Tags: Transl Res Source Type: research
In this study, we investigated ABMSC transplantation as treatment for acute radiation enteritis. We developed a dog model of acute radiation enteritis using abdominal intensity-modulated radiation therapy (IMRT) in a single X-ray dose of 14 Gy.
Source: Translational Research - Category: Research Authors: Source Type: research
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