Negative prognostic impact of epidermal growth factor receptor copy number gain in young adults with isocitrate dehydrogenase wild-type glioblastoma

ConclusionsEGFR CN gain may be associated with inferior outcomes in young adults with newly diagnosed,IDH-WT GBM, suggesting a potential role for targeting EGFR in this population.
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research

Related Links:

ConclusionsAYA in the US experience disparities in cancer survival based on insurance status, independent of late stage of presentation. Patients age 26 ‐39 may be especially vulnerable to health outcomes associated with poor socioeconomic status, treatment disparities, and poor access to care.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Conclusion Astroblastoma is an extremely rare CNS tumor. Morphological diagnosis is difficult, as the typical astroblastic rosettes may be present also in other CNS tumors, including some gliomas and ependymomas. In fact, AB can be considered as a morphologic pattern, which can be associated with a spectrum of molecular entities. Total resection is the best treatment; the precise role of chemotherapy and radiotherapy is still debated, particularly for high-grade tumors. We believe that DNA-methylation profiles represents an important instrument for confirming diagnosis, predicting prognosis and better defining the molec...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
This study was supported by the Shanghai Sailing Program [grant number 17YF1425200, 2017]; Chinese National Natural Science Funding [grant number 81702249, 2017]; Science and Technology Commission of Shanghai Municipality [grant number 17511103403, 2017]; The funder has no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments We acknowledge the ex...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
In conclusion, we have shown the safety and efficacy of Vemurafenib in a pediatric patient with DS affected by PXA. Ethics Statement This study was carried out in accordance with the recommendations of the Internal Review Board of the Bambino Gesù Children's Hospital with written informed consent from all subjects. All subjects gave written informed consent in accordance with the Declaration of Helsinki. The protocol was approved by the Internal Review Board of the Bambino Gesù Children's Hospital. Informed Consent The authors declare that written informed consent was obtained from the pat...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
This study compared clinicopathological features and survival between younger AYAs and children with low-grade glioma (LGG), a common brain tumor among AYAs.MethodsThis was a secondary analysis of Children ’s Oncology Group legacy study CCG-9891/POG-9130, which enrolled participants 0–21 years of age with newly-diagnosed LGG treated with surgery alone. For analysis, participants were categorized as children (0–14 years old) or early AYAs (eAYAs, 15–21 years old) and compared on demographics , clinical presentation, tumor characteristics, surgical outcomes, progression-free survival (P...
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research
AbstractBrain tumors are associated with increased mortality and morbidity and are the most common cancer type in children and young adults. The present review focuses on the interplay between leptin, the most extensively studied adipokine, and the onset, development, and treatment of primary brain and intracranial tumors. The two main mechanisms for increased leptin levels in intracranial tumor survivors, leptin resistance caused by hypothalamic damage, or secondary to obesity, are discussed. The contradicting mechanistic observations on leptin being able to both promote tumorinogenesis (e.g., in gliomas) as well as inhib...
Source: Hormones and Cancer - Category: Cancer & Oncology Source Type: research
(Dartmouth-Hitchcock Medical Center) Brain tumors are responsible for 25 percent of cancer-related deaths in children and young adults. Despite initial response to treatment, most aggressive brain tumors eventually recur and are ultimately incurable. Multiple studies suggest that cancer stem cells within these tumors resist therapy and are responsible for tumor recurrences. Researchers at Dartmouth's Norris Cotton Cancer Center have devised a strategy to treat these tumors by identifying a secretion-mediated pathway that's essential for maintaining glioma cancer stem cells.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
CONCLUSIONS: The literature review suggests that OPN may play important roles in the development and progression of selected cancers of children and young adults, including acute lymphoblastic leukemia, malignant gliomas, AT/RT and Langerhans cell histiocytosis. However, limited number of published studies prevents from definite concluding on the clinical utility of OPN as a marker of diagnosis, prognosis and treatment monitoring in these pediatric cancers. Further studies performed in more numerous groups of patients with particular types of cancers of children and young adults are warranted. PMID: 28326824 [PubMed - ...
Source: Future Medicine: Biomarkers in Medicine - Category: Internal Medicine Tags: Biomark Med Source Type: research
AbstractPurpose of ReviewThis review will discuss the role of several key players in glioma classification and biology, namely isocitrate dehydrogenase 1 and 2 (IDH1/2), alpha thalassemia/mental retardation syndrome X-linked (ATRX), B-Raf (BRAF), telomerase reverse transcriptase (TERT), and H3K27M.Recent FindingsIDH1/2 mutation delineates oligoden-droglioma, astrocytoma, and secondary glioblastoma (GBM) from primary GBM and lower-grade gliomas with biology similar to GBM. Additional mutations including TERT, 1p/19q, and ATRX further guide glioma classification and diagnosis, as well as pointing directions toward individual...
Source: Current Neurology and Neuroscience Reports - Category: Neuroscience Source Type: research
High-grade gliomas are the most common malignant brain tumors in adults. Gliomas represent about 3% of premature cancer death (aged less than 65) and is the 3rd cause of death by cancer for young adults (aged between 15 and 34). Among them, Glioblastoma Multiform (GBM) is the most common tumor. Its incidence is estimated at 5 new cases each year for 100,000 inhabitants. Despite reference treatment, including surgery, radiation oncology and chemotherapy, GBM still remains with a very poor prognosis (median survival below 14.5 months).
Source: Photodiagnosis and Photodynamic Therapy - Category: Laser Surgery Authors: Tags: Poster PN-075 Source Type: research
More News: Brain | Brain Tumor | Cancer | Cancer & Oncology | Cancer in Adolescents | Cancer in Young Adults | Genetics | Glioma | Neurology | Pediatrics | Statistics | Study