Topoisomerase IB poisons induce histone H2A phosphorylation as a response to DNA damage in Leishmania infantum

This report shows for the first time the effect of a series of synthetic indenoisoquinolines on histone H2A phosphorylation, which represents a primary signal of double stranded DNA break in genus Leishmania.Graphical abstract
Source: International Journal for Parasitology: Drugs and Drug Resistance - Category: Parasitology Source Type: research

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Publication date: Available online 21 October 2019Source: Pesticide Biochemistry and PhysiologyAuthor(s): Jeffrey G. Scott, Nicolas BuchonAbstractInsecticides are valuable and widely used tools for the control of pest insects. Despite the use of synthetic insecticides for>50 years, we continue to have a limited understanding of the genes that influence the key steps of the poisoning process. Major barriers for improving our understanding of insecticide toxicity have included a narrow range of tools and/or a large number of candidate genes that could be involved in the poisoning process. Herein, we discuss the numerous...
Source: Pesticide Biochemistry and Physiology - Category: Biochemistry Source Type: research
Nov 5, 2019. . Sponsored by Mississippi Rural Health Association
Source: Rural events via the Rural Assistance Center - Category: Rural Health Source Type: events
Bilbao Gloria Yaluff Guzmán Alvarez Chagas disease and Leishmaniasis are neglected endemic protozoan diseases recognized as public health problems by the World Health Organization. These diseases affect millions of people around the world however, efficient and low-cost treatments are not available. Different steroid molecules with antimicrobial and antiparasitic activity were isolated from diverse organisms (ticks, plants, fungi). These molecules have complex structures that make de novo synthesis extremely difficult. In this work, we designed new and simpler compounds with antiparasitic potential inspired ...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Condition:   Paraquat Poisoning Interventions:   Drug: Levothyroxine Sodium;   Drug: Traditional therapy Sponsors:   Second Affiliated Hospital, School of Medicine, Zhejiang University;   First People's Hospital of Hangzhou;   Zhejiang Provincial Hospital of TCM Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Paraquat Poisoning Interventions:   Drug: Levothyroxine Sodium;   Drug: Traditional therapy Sponsors:   Second Affiliated Hospital, School of Medicine, Zhejiang University;   First People's Hospital of Hangzhou;   Zhejiang Provincial Hospital of TCM Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
 Psychiatric medications are the religion and politics of the mental health advocacy world — don’t bring them up unless you want a fight to break out. Luckily, here at Not Crazy, we don’t shy away from confrontation.  In this episode, we cover the good, the bad, and the ugly surrounding medications. Like whether or not you should take them. We tackle side effects like feeling numb and sexual dysfunction and share our personal histories with medication therapy. Listen now! (Transcript Available Below) SUBSCRIBE &REVIEW About The Not Crazy Podcast Hosts Gabe Howard is an award-winning wri...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Antidepressant Antipsychotic General Medications Mental Health and Wellness Not Crazy Podcast Psychology Research Sexuality Stimulants Treatment Source Type: blogs
(Natural News) According to the American Skin Association, allergic reactions caused by poison ivy and similar plants affect a whopping 50 million people in America annually. If you’re suffering from poison ivy rash, use natural remedies like aloe vera or oatmeal to relieve your condition. (h/t to HomesteadSurvivalSite.com) The leaves, stems, and roots of poison ivy all contain...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
lav Yurchenko Here we report sequence and phylogenetic analysis of two new isolates of Leishmania RNA virus 2 (LRV2) found in Leishmania major isolated from human patients with cutaneous leishmaniasis in south Uzbekistan. These new virus-infected flagellates were isolated in the same region of Uzbekistan and the viral sequences differed by only nineteen SNPs, all except one being silent mutations. Therefore, we concluded that they belong to a single LRV2 species. New viruses are closely related to the LRV2-Lmj-ASKH documented in Turkmenistan in 1995, which is congruent with their shared host (L. major) and common geographical origin.
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research
Publication date: Available online 19 October 2019Source: Comparative Biochemistry and Physiology Part C: Toxicology &PharmacologyAuthor(s): Shouta M.M. Nakayama, Ayuko Morita, Yoshinori Ikenaka, Yusuke K. Kawai, Kensuke P. Watanabe, Chihiro Ishii, Hazuki Mizukawa, Yared B. Yohannes, Keisuke Saito, Yukiko Watanabe, Masaki Ito, Natsuo Ohsawa, Mayumi IshizukaAbstractWorldwide use of anticoagulant rodenticides (ARs) for rodents control has frequently led to secondary poisoning of non-target animals, especially raptors. In order to suggest some factors that may help considering the mechanism of the incidents, this study fo...
Source: Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology - Category: Toxicology Source Type: research
by Craig Klugman, Ph.D. The Resident (Season 3; Episode 4): Hubris and Assault; New Amsterdam (Season 2; Episode 4): Taking medicine to the streets, assisted suicide, lead poisoning The Resident (Season 3; Episode 4): Hubris and Assault Hades is a social media white supremacist celebrity comes in with a headache and a history of brain arteriovenous malformation (AVM). He says he does not want Pravesh (Indian), Nevins (female), or Feldman (Jewish) touching him. Cain (African-American) offers to do his surgery even though the patient is a violent racist.…
Source: blog.bioethics.net - Category: Medical Ethics Authors: Tags: BioethicsTV Featured Posts Source Type: blogs
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