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Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Source Type: research

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This study analysed the effect of inhaled iloprost and oral sildenafil combination therapy (ilo-sil) on pulmonary haemodynamic parameters in patients with secondary pulmonary hypertension.
Source: Heart, Lung and Circulation - Category: Cardiology Authors: Tags: Original Article Source Type: research
THE PERIOPERATIVE management of lung transplantation patients has advanced significantly over the past 56 years since the initial lung transplant was performed by Hardy in 1963.1,2 This advancement not only is limited to basic and clinical scientific achievements, but also extends to team-based coordination of lung transplantation care.1,3 Beginning with the isolated work of Demikhov, to the multidisciplinary Toronto Lung Transplant Group and formation of the International Society for Heart and Lung Transplantation (ISHLT), the evolution of perioperative management has been concomitant with a rise in multidisciplinary teamwork.
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Expert Review Source Type: research
Cardiac rehabilitation (CR), or “cardiac rehab,” is a multifaceted, medically supervised program proven to improve heart health and outcomes in people with certain types of cardiovascular disease. CR revolves around three major components: an individualized exercise and training program, education on topics related to heart health, and stress reduction. CR is currently recommended for the following diagnoses: angina (chest pain); heart attack with or without angioplasty or bypass surgery; heart failure with reduced ejection fraction (HFrEF); and heart surgery including heart valve procedures or heart or heart/l...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Exercise and Fitness Health Heart Health Source Type: blogs
Bansal et al. demonstrated that the fully magnetically levitated centrifugal-flow HeartMate3 (HM3) left ventricular assist device is associated with greater preservation of the structure of vWF HMWMs than the HeartMateII (HMII) mechanical bearing axial-flow pump.1 The findings confirm our prior work regarding the development of AVWS in VAD patients and the less distinct loss of the vWF high molecular weight multimers in HM3 patients compared with HMII patients.2,3 However, there are some differences: Bansal et al.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Case Anecdotes, Comments and Opinions Source Type: research
In this study we analyzed the quality and quantity of the structure of vWF by using mulitmer gel electrophoresis and also evaluated VWF functional activities, including platelet glycoprotein I β binding (VWF:Act LIA) and Factor VIII activity, to assess for acquired vWD (aVWD) with commercially available methods that are used in clinical practice and previously validated in congenital vWD.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Despite advances in our understanding of primary graft dysfunction (PGD) – acute lung injury in the first 72 hours after transplant – it remains a serious complication with little change in incidence over time. The main focus of the PGD literature has been on risk factor identification and modification, given limited success with therapeutic interventions.1 One of th e recipient-related risk factors that has received attention has been obesity as defined by the body mass index (BMI), in particular because BMI-related risk is potentially modifiable.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Editorial Source Type: research
AbstractPurposeThe pulmonary artery (PA) in patients with pulmonary hypertension (PH) becomes dilated. We analyzed the postoperative changes of the main PA after lung transplantation (LuTx).MethodsThe subjects of this retrospective study were 68 LuTx recipients, divided into a PH group (n = 36) and a non-PH group (n = 32), based on preoperative right heart catheterization findings. The PA diameter was measured on chest computed tomography. We evaluated the correlation between the mean pulmonary arterial pressure (mPAP) and the main PA diameter and compared the main PA diameters before and 3 ...
Source: Surgery Today - Category: Surgery Source Type: research
Abstract Pulmonary hypertension is a term used to describe a complex multifactorial group of conditions diagnosed by an elevated mean pulmonary artery pressure of 20 mm Hg or higher on right heart catheterization. The diagnosis of pulmonary hypertension in pregnancy is important, as it is associated with high rates of maternal morbidity and mortality, even with modern management. Diagnostic testing is important for establishing the diagnosis, type, and severity of pulmonary hypertension, which in turn, dictates treatment options. Echocardiographic assessment is the first step in diagnosis and the gold standard for...
Source: Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Obstet Gynecol Source Type: research
Abstract BACKGROUND: Heart-lung transplantation (HLTx) is an effective treatment for patients with advanced cardiopulmonary failure. However, no large multicenter study has focused on the relationship between donor and recipient risk factors and post-HLTx outcomes. Thus, we investigated this issue using data from the United Network for Organ Sharing database. METHODS: All adult patients (age ≥18 years) registered in the United Network for Organ Sharing database who underwent HLTx between 1987 and 2017 were included (n=997). We stratified the cohort by patients who were alive without retransplant at 1 year ...
Source: Circulation - Category: Cardiology Authors: Tags: Circulation Source Type: research
Conclusion: Idiopathic pulmonary arterial hypertension is associated with poor prognosis and survival despite advancements of disease specific therapies. Higher mortality in our study is due to delayed presentation and diagnosis. Also lack of availability of prostacyclins and lung transplantation in advanced stages of disease contribute to higher mortality in Indian setup. Non-invasive echocardiographic factors and six minute walk distance are important prognostic factors that help in disease severity stratification to identify patients in need of intensive medical management. PMID: 31571454 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
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