Topical Ectoine: A Promising Molecule in the Upper Airways Inflammation-A Systematic Review.

Topical Ectoine: A Promising Molecule in the Upper Airways Inflammation-A Systematic Review. Biomed Res Int. 2019;2019:7150942 Authors: Casale M, Moffa A, Carbone S, Fraccaroli F, Costantino A, Sabatino L, Lopez MA, Baptista P, Cassano M, Rinaldi V Abstract To date, topical therapies guarantee a better delivery of high concentrations of pharmacologic agents to the mucosa of the upper airways (UA). Recently, topical administration of ectoine has just been recognized as adjuvant treatment in the Allergic Rhinitis (AR) and Rhinosinusitis (ARS). The aim of this work is to review the published literature regarding all the potential therapeutic effects of ectoine in the acute and chronic inflammatory diseases of UA. Pertinent studies published without temporal limitation were selected searching on MEDLINE the following terms: "ectoine" and "nasal spray," "oral spray," "upper respiratory tract infections," "rhinosinusitis," "rhinitis," "rhinoconjunctivitis," "pharyngitis," and "laryngitis." At the end of our selection process, six relevant publications were included: two studies about the effect of ectoine on AR, one study about ARS, one study about rhinitis sicca anterior, and two studies about acute pharyngitis and/or laryngitis. Due to its moisturizing and anti-inflammatory properties, topical administration of ectoine could play a potential additional role in treatment...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research

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We report the case of a 5-year-old male patient, with a history of allergic rhinitis admitted in our clinic for acute onset fever refractory to antipyretics, chest pain, anorexia, refusal of solid food, accepting only small amounts of fluids, odynophagia, and epigastric pain. The clinical exam revealed severe malaise, pallor, decreased skin turgor, abdominal epigastric tenderness, heartburn at palpation within the epigastric area. The laboratory tests showed leukocytosis, monocytosis, hypoglycaemia, and elevated inflammatory biomarkers. Diagnoses: The serology tests for human immunodeficiency virus (HIV), cytomegaloviru...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
ConclusionsNasal patency was lower in children with restless sleep, rhinitis signs and symptoms, hard palate width reduced and with changes in mastication, deglutition and speech functions. It is also emphasized that most of the children presented signs and symptom of allergic rhinitis.ResumoIntroduçãoA obstrução nasal é um sintoma comum na infância relacionado a rinite e hipertrofia das tonsilas faríngeas. Na presença de obstrução nasal, a patência nasal pode estar reduzida e a respiração nasal ser substituída por respira&ccedi...
Source: Brazilian Journal of Otorhinolaryngology - Category: ENT & OMF Source Type: research
Conclusion: Children with BA and nasal symptoms are characterized by combined and multimorbid forms of upper respiratory tract pathology.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research
Question: A 41-year-old male was referred for endoscopy for a history of chronic post-prandial epigastric pain, early satiety, bloating and occasional vomiting. He denies any diarrhea or unintentional weight loss. Past medical history includes migraine headaches, ADHD, depression, allergic rhinitis and ganglion cyst excision from left wrist. Current medications include Methylphenidate, Escitalopram, Aripiprazole, Fluticasone and Rizatriptan. Physical exam was normal. Previous upper endoscopy revealed diffuse inflammation throughout the entire stomach along with duodenal nodularity.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Practical Teaching Case Source Type: research
Publication date: May 2018 Source:The Kaohsiung Journal of Medical Sciences, Volume 34, Issue 5 Author(s): Mitsuyo Mieda, Hiroshi Miyashita, Hiroyuki Osawa, Tomosuke Hirasawa, Nobuko Makino, Sachiko Toma, Takeshi Tomiyama, Yoshimasa Miura, Alan K. Lefor, Hironori Yamamoto Transnasal endoscopy is widely used in screening for upper gastrointestinal lesions because of less associated pain. Nasal bleeding is the most severe adverse effect, but specific risk factors have not been identified. The aim of this study is to identify risk factors for nasal bleeding during transnasal endoscopy. Nasal bleeding occurred in 160/3035 (5....
Source: The Kaohsiung Journal of Medical Sciences - Category: Universities & Medical Training Source Type: research
ConclusionOur results suggest that small inhalant pollutants may contribute to nonallergic symptomatology in patients with and without nasal polyps. Regardless of allergy status, BC may play a role in CRS symptom severity.
Source: International Forum of Allergy and Rhinology - Category: Allergy & Immunology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Conclusions Nasal patency was lower in children with restless sleep, rhinitis signs and symptoms, hard palate width reduced and with changes in mastication, deglutition and speech functions. It is also emphasized that most of the children presented signs and symptom of allergic rhinitis.
Source: Brazilian Journal of Otorhinolaryngology - Category: ENT & OMF Source Type: research
Conclusion. Even in the absence of skin diseases, the prevalence of sensitization to metals (patch test) is greater in nonallergic and overlapping rhinitis, as compared to allergic rhinitis and controls. PMID: 28497672 [PubMed - in process]
Source: European Annals of Allergy and Clinical Immunology - Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research
CONCLUSION: Among various general health problems, our study found that NSD was associated with asthma only when NSD was accompanied by a chronic nasal obstructive symptom. PMID: 26980380 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - Category: ENT & OMF Authors: Tags: Am J Rhinol Allergy Source Type: research
ConclusionOur results showed that HMGB1 is secreted into the extracellular area space in the upper airway, and HMGB1 levels in nasal lavage fluid correlate with severity of inflammation, as assessed by the Lund‐Mackay staging system for chronic rhinosinusitis. These results provide evidence for HMGB1 as an inflammatory mediator associated with the severity of chronic rhinosinusitis. Level of EvidenceN/A. Laryngoscope, 2015
Source: The Laryngoscope - Category: ENT & OMF Authors: Tags: Allergy/Rhinology Source Type: research
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