Topical Ectoine: A Promising Molecule in the Upper Airways Inflammation-A Systematic Review.

Topical Ectoine: A Promising Molecule in the Upper Airways Inflammation-A Systematic Review. Biomed Res Int. 2019;2019:7150942 Authors: Casale M, Moffa A, Carbone S, Fraccaroli F, Costantino A, Sabatino L, Lopez MA, Baptista P, Cassano M, Rinaldi V Abstract To date, topical therapies guarantee a better delivery of high concentrations of pharmacologic agents to the mucosa of the upper airways (UA). Recently, topical administration of ectoine has just been recognized as adjuvant treatment in the Allergic Rhinitis (AR) and Rhinosinusitis (ARS). The aim of this work is to review the published literature regarding all the potential therapeutic effects of ectoine in the acute and chronic inflammatory diseases of UA. Pertinent studies published without temporal limitation were selected searching on MEDLINE the following terms: "ectoine" and "nasal spray," "oral spray," "upper respiratory tract infections," "rhinosinusitis," "rhinitis," "rhinoconjunctivitis," "pharyngitis," and "laryngitis." At the end of our selection process, six relevant publications were included: two studies about the effect of ectoine on AR, one study about ARS, one study about rhinitis sicca anterior, and two studies about acute pharyngitis and/or laryngitis. Due to its moisturizing and anti-inflammatory properties, topical administration of ectoine could play a potential additional role in treatment of acute and chronic inflammatory diseases of UA, in particular in t...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research