Vibration May Dull Pain From Anesthetic Injection Vibration May Dull Pain From Anesthetic Injection

A vibratory stimulus reduces pain from anesthetic injections given before skin cancer surgery, and is most effective for patients who don't catastrophize pain, according to new findings.Reuters Health Information
Source: Medscape General Surgery Headlines - Category: Surgery Tags: Anesthesiology News Source Type: news

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Authors: Sheriff T, Lin MJ, Dubin D, Khorasani H Abstract Cannabis is increasingly being used world-wide to treat a variety of dermatological conditions. Medicinal cannabis is currently legalized in Canada, 31 states in America and 19 countries in Europe. The authors reviewed the literature on the pharmacology and use of cannabinoids in treating a variety of skin conditions including acne, atopic dermatitis, psoriasis, skin cancer, pruritus, and pain. Cannabinoids have demonstrated anti-inflammatory, antipruritic, anti-ageing, and antimalignancy properties by various mechanisms including interacting with the newly ...
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
ConclusionsThe integrated clinical safety data indicated that RM-1929 PIT treatment had a favorable safety profile with no unexpected safety concerns.Clinical trial identificationNCT02422979.Legal entity responsible for the studyRakuten Medical, Inc.FundingRakuten Medical, Inc.DisclosureJ.M. Johnson: Advisory / Consultancy: Foundation Medicine; Research grant / Funding (institution): BMS; Research grant / Funding (institution): Merck; Research grant / Funding (institution): AstraZeneca. J.M. Curry: Research grant / Funding (institution): AstraZeneca. S.T. Kochuparambil: Shareholder / Stockholder / Stock options, Full / Par...
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
Background/Aims: As a malignant and melanocytic tumor, cutaneous melanoma is the devastating skin tumor with high rates of recurrence and metastasis. Bone is the common metastatic location, and bone metastasis may result in pathologic fracture, neurologic damage, and severe bone pain. Although metastatic melanoma was reported to get benefits from immunotherapy, molecular mechanisms and immune microenviroment underlying the melanoma bone metastasis and prognostic factors are still unknown.Methods: Gene expression profiling of 112 samples, including 104 primary melanomas and 8 bone metastatic melanomas from The Cancer Genome...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
In this study we aimed to elicit the impact of different palliative therapy options on survival in a nationally representative sample of sinonasal cancer patients.MethodsNational Cancer Database 2004 ‐2015 data sets were queried for cases of primary sinonasal cancer (N = 380). Kaplan‐Meier analysis was utilized to determine median overall survival (M‐OS) and overall survival (OS) among the different treatment cohorts (pain management, palliative radiation therapy, palliative chemotherapy, palliative surgery, and combination therapy). Prognostic factors were elicited by comparing OS by log‐rank tests and subsequent ...
Source: International Forum of Allergy and Rhinology - Category: Allergy & Immunology Authors: Tags: ORIGINAL ARTICLE Source Type: research
We examined the relationship between nitrogen mustard (NM)-induced lymphomatoid papulosis (LyP) in patients with mycosis fungoides (MF). Nine patients were included who were initially diagnosed with MF and subsequently developed LyP in the setting of NM induced inflammation. The average time from initiation of NM therapy to development of LyP was 5.2 months. The majority of patients presented to their follow-up visit with new red bumps, most commonly located on the buttocks/lower extremities, with symptoms of pain and pruritus in 6/9 patients.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Melanoma and Other Skin Cancers Source Type: research
Publication date: Available online 27 August 2019Source: Journal of Geriatric OncologyAuthor(s): Terufumi Kawamoto, Naoto Shikama, Masaki Oshima, Yasuo Kosugi, Masahiko Tsurumaru, Keisuke SasaiAbstractObjectivesConsidering that therapeutic strategies for older adult patients with esophageal cancer (EC) remain controversial, we aimed to assess the safety of radiotherapy with concurrent docetaxel (DOC-RT) among older adult patients with EC.Materials and MethodsEligible patients included those aged ≥76 years who were diagnosed with esophageal squamous cell carcinoma. Patients received radiotherapy (60 Gy in 30 fraction...
Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
Although seborrheic keratoses are one of the most commonly seen lesions in dermatology, they can present in unusual ways. Here we describe a unique presentation of eruptive seborrheic keratoses. A 64-year-old female presented with lesions that erupted suddenly all over her skin over the past few months. The lesions were steadily enlarging, tender and pruritic. The patient denied a personal history of cancer, including skin cancer. She also denied weight loss, fevers, chills, night sweats, abdominal pain or change in stool caliber.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Background: Nonmelanoma skin cancer (NMSC) includes basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) and are the most common skin cancers in the world. This term also encompasses more rare, but aggressive tumors such as sebaceous carcinoma. Many NMSC are detected and treated in the earlier stages of development, however, if left untreated, NMSC can grow to become large, ulcerating, locally destructive, and malignant tumors that may cause functional impairment, significant pain, and bleed frequently.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
We report a case of squamous cell carcinoma secondary to plantar wart in a 72-year-old Chinese woman. 20 years previously the patient found a 1-cm round grayish yellow plaque on her right heel. The lesion was diagnosed as plantar wart by every dermatologist the patient consulted, and can be gradually subsided after treatment such as cryotherapy and photodynamic therapy, but recurred frequently. 2 years previously the plaque enlarged accompanying with aggravated pain, biopsy indicated verrucous hyperplasia.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Carcinogenesis and Cancer Genetics Source Type: research
Authors: Xu K, Wang J, Yang L, Wan L, Wang Y Abstract Malignant melanoma is a type of skin cancer with high morbidity and mortality. Therapeutic strategies should be individualized in order to increase the survival rate. The aim of this study was to assess the effect of lidocaine on skin healing and immune function after operation of patients with melanoma. Sixty patients with melanoma were selected from those treated in Bishan Hospital between August 2014 and August 2016. The patients were randomly divided into lidocaine group and control group. Lidocaine group was locally treated with an intradermic injection of ...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
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