Walking on the Moon: a Randomized Clinical Trial on the Role of Lower Body Positive Pressure Treadmill Training in Post-Stroke Gait Impairment
Publication date: Available online 19 September 2019Source: Journal of Advanced ResearchAuthor(s): Rocco Salvatore Calabrò, Luana Billeri, Veronica Agata Andronaco, Maria Accorinti, Demetrio Milardi, Antonino Cannavò, Enrico Aliberti, Angela Militi, Placido Bramanti, Antonino NaroAbstractBody weight–supported treadmill training (BWSTT) can be usefully employed to facilitate gait recovery in patients with neurological injuries. Specifically, lower body positive pressure support system (LBPPSS) decreases weight-bearing and ground reaction forces with potentially positive effects on qualitative gait indices. However, which gait features are being shaped by LBPPSS in post-stroke patients is yet poorly predictable. A pilot study on the effects of LBPPSS on qualitative and quantitative gait indices was carried out in patients with hemiparesis due to stroke in the chronic phase. Fifty patients, who suffered from a first, single, ischemic, supra-tentorial stroke that occurred at least 6 months before study inclusion, were enrolled in the study. They were provided with 24 daily sessions of gait training using either the AlterG device or conventional treadmill gait training (TGT). These patients were compared with 25 age-matched healthy controls (HC), who were provided with the same amount of AlterG. Qualitative and quantitative gait features, including Functional Ambulation Categories, gait cycle features, and muscle activation patterns were analyzed before and aft...
CONCLUSIONS: The study demonstrates the high frequency of social cognition impairment 3 years after the first-ever stroke in young patients. Doctors and nurses should be sensitized to cognitive handicap after stroke because of difficulties for rehabilitation and returning to work. PMID: 31633560 [PubMed - as supplied by publisher]
Authors: Varvat J, Montmartin A, Epinat M, Accassat S, Garcin A, Li G, Garnier P, Lambert C, Mismetti P, Mallouk N Abstract BACKGROUND AND PURPOSE: Biological response to clopidogrel prescribed after a non-cardioembolic ischemic stroke or transient ischemic attack (TIA) has been little studied. The aim of our study (AAPIX) was to assess this response and investigate the agreement between different biological assays in revealing poor responders. METHODS: Patients hospitalized following a non-cardioembolic ischemic stroke or transient ischemic attack (TIA) and prescribed clopidogrel were consecutively included fr...
In conclusion, this study indicated that lncRNA ROR could promote the cerebral H/R injury by inhibiting the expression of miR-135a-5p or upregulating the expression of ROCK1/2. And, miR-135a-5p overexpression could improve the cerebral H/R injury by inhibiting the expression of ROCK1/2. PMID: 31632583 [PubMed]
ConclusionsThe study is designed to identify a TxA dose with maximal efficacy and minimal complications. We hypothesize that the high dose has superior efficacy and non-inferior safety to the low dose.
In conclusion, CBL ameliorated cerebral ischemia injury through reducing neuroinflammation partly via the activation of CREB/PGC-1α pathway and may play a therapeutic role as anti-neuroinflammatory agents in the brain disorders associated with neuroinflammation.
A 68-year old man with a history of hypertension, diabetes, coronary artery disease and an obliterating lower limbs arteritis, presented for a stroke. Electrocardiogram did not show atrial fibrillation nor ischemic electrocardiographic signs. White blood cell count (10800/m3) was high but eosinophil count (234/mm3) was normal. Atherosclerosis origin of the stroke was suspected.
HUK combined with NBP can enhance AIS patients' long ‐term independency rate, and the effectiveness of HUK combined therapy is better than Eda. AbstractAimThe effectiveness of neuroprotective agents is still unclear. Here we analyzed the clinical outcomes of acute ischemic stroke (AIS) patients treated with human urinary kallidinogenase (HUK) or edaravone (Eda) combined with butylphthalide (NBP).MethodsFrom January 2016 to December 2017, a total of 165 AIS patients were enrolled in this open ‐label, randomized controlled clinical study. Patients were randomly allocated into HUK group and Eda group in a ratio of 2:1. Al...
CONCLUSIONS: Overall, hypothermia offers clinical benefit, most likely through its effects on the inflammatory response.